SciLifeLab DDD Platform – built for function

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Presentation transcript:

SciLifeLab DDD Platform – built for function Operational since Q2-2014 40+ Industrially experienced scientists 12 Academic professors – Area expertize and network National Platform board – Project prioritization, budget and strategy Håkan Billig (GU, Chair), Tommy Olsson (UmU), Maria Jenmalm (LiU), Mef Nilbert (LU) Anna Sandström (AZ), Kjell Sackariassen (KellSA), Bo Öberg (ex Medivir) Per Arvidsson Kristian Sandberg Target product profiling & Drug safety assessment Distribute compounds in assay ready plates from the SciLifeLab compound collection Compound Center Platform and project coordination. Assessment of liabilities driven by target, SM or Biologics. Support to PI’s and Innovation offices Protein expression & characterization Human antibody therapeutics Selection and characterization of therapeutic antibody candidates from IP - free human phage libraries SciLifeLib 1 & 2 Prepare, purify and characterize proteins from E. coli, insect and transient HEK cells Protein Prepare, compare and design lead molecules with a promising profile for proof-of-concept in vivo. Access to radio chemistry and peptide chemistry Medicinal chemistry – Lead ID Medicinal chemistry - Hit2Lead Prepare, compare and design lead molecules with a promising profile for proof-of-concept in vivo. Chemistry Biochemical and cellular screening Investigate drug MoA for product differentiation and identification of putative biomarkers In vitro & systems pharmacology Develop and run assays required to drive chemistry and to confirm functional binding of antibodies Assays Biophysical screening & characterization ADME (UDOPP) Identify and characterize ligands, structural biology & fragment based lead generation Determine absorption, distribution, metabolism, excretion (ADME) and perform pharmaceutical profiling