ICEOS 2016 Pelvic obliquity correction in distraction based growing spine constructs Mathew Schur BA1, Lindsay M Andras MD1, Nicholas R Gonsalves MD1,

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ICEOS 2016 Pelvic obliquity correction in distraction based growing spine constructs Mathew Schur BA1, Lindsay M Andras MD1, Nicholas R Gonsalves MD1, Paul D Sponseller MD MBA2, John B Emans MD3, Michael G Vitale MD MPH4, David L Skaggs MD MMM1, Growing Spine Study Group, Children’s Spine Study Group 1.Children's Orthopaedic Center, Children's Hospital Los Angeles; 2.Department of Orthopaedic Surgery, Johns Hopkins Children’s Hospital, Johns Hopkins University; 3.Department of Orthopaedic Surgery, Boston Children’s Hospital, Harvard Medical School; 4. Department of Orthopaedic Surgery , New York-Presbyterian Morgan Stanley Children’s Hospital, Columbia University Medical Center

Disclosures Mathew Schur BA – None Grants/Research Support Consultant Stock/Shareholder Speakers’ Bureau Other Financial Support Board/Committee member Mathew Schur BA – None Lindsay M. Andras MD – Eli Lilly (c); Biomet & Medtronic (d); SRS, POSNA, JPO (e); Orthobullets (f); Nicholas R. Gonsalves MD - None Paul D. Sponseller MD, MBA –DePuy (a, b, f); Globus Medical (f); Journal of Bone and Joint Surgery (e); Journal of Bone and Joint Surgery Oakstone Medical (f); SRS (e) John Emans MD – Journal of Children’s Orthopedics (e); Medtronic (b); Synthes (b, f) Michael G Vitale MD, MPH – Biomet (a, b & e); Children’s Spine Foundation (a & f); DePuy, A Johnson & Johnson Company (e); FOX, Children’s Spine Foundation (e); IPOS (f); Medtronic (e); OMEGA (e); OREF (a); POSNA (a & f); SRS (a); OSRF (a); Stryker (b); Synthes (e); Wellinks (b) David L. Skaggs MD MMM – Ellipse, POSNA (a), GSSG & GSF (e); SRS (a, e); ZimmerBiomet (b, d, e); Medtronic (b, d, e); Zipline Medical, Inc. (b, c); Orthobullets (b, c); Grand Rounds (b); Green Sun Medical (b, c); Johnson & Johnson (d); Wolters Kluwer Health - Lippincott Williams & Wilkins; Biomet Spine (e)

Background The use of pelvic fixation in growing spine constructs allows for improvement of the significant pelvic obliquity that can occur in patients with early-onset scoliosis (EOS) Multiple options exist to provide this fixation and little comparative data is available

(Iliac screws/Sacral Alar Iliac Screws) Objective To determine if there is a difference in the correction of pelvic obliquity by different types of pelvic fixation Screw group (Iliac screws/Sacral Alar Iliac Screws) S Hooks

Methods Neuromuscular, syndromic, and congenital EOS patients treated with distraction based implants with pelvic fixation from 1990 to 2013 were reviewed from two EOS multicenter databases Patients were divided into groups by type of pelvic fixation: Screw group (SAI/Iliac screw) vs S hook group Patients with less than 2 year follow-up or index instrumentation at ≥ 10 years of age were excluded Statistical significance analyzed via t-test

154 patients met the inclusion criteria: Results 154 patients met the inclusion criteria: Screw group=41 patients (Iliac screws=29;Sacral-alar-iliac (SAI) screws=12) S hook fixation=113 patients

Results Better Pelvic obliquity correction observed in the screw group than the S hook group Type of pelvic fixation Mean preoperative pelvic obliquity (degrees) Mean postoperative pelvic obliquity (degrees) Mean pelvic obliquity correction (degrees) Percent correction (%) P-value Iliac/SAI screws 34.2 ± 11.9 8.2 ± 5.7 26.1 ± 11.9 74 0.039* S hooks 31.3 ± 9.2 14.0 ± 9.5 17.3 ± 9.2 57

No difference in change in T1-S1 or Cobb correction Type of pelvic fixation Mean preoperative T1-S1 length (mm) Mean postoperative T1-S1 length (mm) Mean T1-S1 length change (mm) P-value Iliac/SAI screws 261.4 301.8 40.4 0.90 S hooks 238.3 277.8 39.5 Type of pelvic fixation Mean preoperative Cobb angle (degrees) Mean postoperative Cobb angle (degrees) Mean Cobb angle correction (degrees) Percent correction (%) P-value Iliac/SAI screws 80.9 49.6 31.2 33% 0.13 S hooks 72.7 48.6 24.1 31%

Results A trend toward more complications observed in S hook group than screw group but this did not reach statistical significance Type of pelvic fixation Complications P-value Iliac/SAI screws 14.6% (6/41) 0.21 S hooks 25.7% (29/113)

Discussion Screws (iliac/SAI screws) achieved better correction of pelvic obliquity than S hooks (p= 0.039) No difference was found in the increase in T1-S1 length (p=0.90) or Cobb angle correction (p=0.13) between the groups Rate of complications for the S hook group was greater than the screw group, although not statistically significant

Conclusion In distraction based growing spine constructs, pelvic fixation with screws achieved better correction of pelvic obliquity than S hooks

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