MedStar Health Research Institute How to Solicit a Grant from the Federal Government and Who Should We Apply To? Jason G. Umans, MD, PhD MedStar Health Research Institute Georgetown-Howard Universities Center for Clinical and Translational Science

I have no real or apparent conflicts of interest to report. Jason G. Umans, MD I have no real or apparent conflicts of interest to report.

Roadmap for next 9 minutes Focus on the NIH Brief mention of FDA, AHRQ, CMS Focus on young investigators Preparation and credibility Career transitions, independence, team science Funding opportunities, PAs, RFAs, Information sources Obvious questions that most ignore

Bubbles-not just in housing

NHLBI funding by mechanism http://www.nhlbi.nih.gov/funding/index.htm Grant Program Percentile Priority Score Description R01 10.0   Research Project Grant   ESI 20.0*   Early Stage Investigator R21 Discontinued (as were the R03s) R15 20 Academic Research Enhancement Awards R41, R42 Small Business Technology Transfer (STTR) Grants R43, R44 25 Small Business Innovation Research Grants (SBIR) P01 15 Program Project Grant   P01 Subproject   Program Project Grant: Subproject K awards 19 Career Development Awards

Do I (Should I) Want a K. K-kiosk: http://grants. nih 5 full years of 75% effort and salary Funding lines of 15-40% Salary of $75k; Research funds $25-50k Need a mentor (with a training track record) Institutional support, environment, resources Money to actually do the proposed research Clear pathway to independence

The CTSAs: Thinking Differently Network of 60 CTSA institutions/consortia Translational research and training infrastructure Focus on multidisciplinary team science All have K(L2) programs (3-5y) All have pilot grant programs All have core labs and services

The Credible Applicant Has had research (not just clinical) training Publications (with convincing contributions) Small, independent grants (from non federal or pilot grant sources—remember the NHLBI is out of this business) Project experience Collaborators and Mentors, as needed-you’re never really “independent” Resources to ensure success And…a great proposal!

What’s out there? Read the Institute web pages Subscribe to and read the (weekly) NIH Guide http://grants.nih.gov/grants/guide/index.html Program Announcements (PAs) (the playing field is not level) Requests for Applications (RFAs) Don’t be the last one to find out

How do they know? Talk with the program officer They actually want to help you You can go back again and again Institute website, priorities Conferences (to set funding priorities) Contracts, Cooperative Networks

Summary of Key Questions Decide if you want to do investigator-initiated research? Do you like running your own show, working in a team, or a hybrid? Are you ready for prime time research funding? And are the resources adequate to do the research? Is a K award appropriate or useful? What else should I do to develop my career?

Summary of Key Questions Am I in the right place, with the right resources, the right mentor, and the right collaborators? Do I know where to look for funding opportunities and how willing am I to adapt my research to NIH priorities? Do I love this crazy life?