Dr. Brian Lipscomb Office: HLSC 346 Email: blipscom@su.edu Office Hours: T 10:00-12:00; Fri. 2:30-4:30 Lecture Times: MWF 10:00-10:50 Gregory 114 MWF 11:00-11:50 Gregory 114

Required Texts Human Anatomy & Physiology (9th or 10th Edition) Elaine N. Marieb , Katja Hoehn Benjamin Cummings

Online Resources: Power Point files used in lecture will be posted on the web. POSTED LECTURE FILES ARE NOT A SUBSTITUE FOR ATTENDING LECTURE OR READING YOUR TEXTBOOK. Handouts and diagrams to be used for class will be posted. Material to be reviewed and printed for lab will also be posted online.

A and P II Intro Contact Information Using Slides Grades Class Expectations What is this Course about? Handouts: Basic Cell Marieb-none

Grading Policy There are a total of 520 points associated with the course: Test 1: 80 pts Test 2: 70 pts Test 3: 65 pts Test 4: 80 pts (given with final) Final: 50 pts (Cumulative- focuses on material from Tests 1-3) Homework: 20 pts (4 X 5 pts) Lab: 155 pts 

Grading Scale: A 468-520 pts B 416-467 pts C 364-415 pts D 312-363 pts  

Attendance and Classroom Behavior Disruptive behavior in class will not be tolerated. Texting, web browsing, searching for Pokemon, excessive talking, etc. is annoying to your fellow students. You may use computers in class, but limit your activities to taking notes or this privilege may be revoked. .  

Laboratories Labs will be held at the Health and Life Sciences Building, 305. Labs begin the week of August 22nd!

Class Expectations Study Attend Lecture Ask Questions Don’t Get too Far Behind in Class Be Respectful in Class and Lab

Blood Blood Intro Blood Plasma Cells of the Blood Stem Cells Marieb 17 Be able to define hematocrit and describe the contents of the layers that are revealed when spinning down blood. Be able to identify some of the principle functions of blood. Be able to describe the cellular and molecular characteristics of RBCs that allow them to carry O2 throughout the body. Be able to identify the formed elements and where they are formed. Be able to describe the concepts of potency, lineage, and commitment specifically in relation to RBCs. Marieb 17

Spinning Down Blood Blood Plasma Buffy Coat: Leukocytes Platelets Erythrocytes Hematocrit Buffy coat varies as white cell numbers go up and down Hematocrit is a simple measure of the bodies ability to carry O2 Blood is a connective tissue: cells(formed elements) and matrix (plasma)

Functions of Blood Distribution of molecules Regulation of heat, pH, blood pressure Protection Endocrine glands pump hormones into blood We will discuss O2 and CO2 movement in detail in respiratory lectures Blood pH is highly controlled Clotting is NOT part of the immune response

Blood Plasma Straw colored 90% H2O 8% Plasma Proteins Dissolved gases, ions, hormones, nutrients and waste

Plasma Proteins Albumins α,β Globulins Fibrinogen γ Globulins Albumins, A,B made in liver Albumins, A, B transport molecule for lipids, fat soluble vitamins and some metal ions Fibrinogen- clotting gamma- antibodies

Formed Elements Erythrocytes Red Blood Cells (RBCs) Leukocytes White Blood Cells Platelets Form in red bone marrow

Erythrocytes: Red Blood Cells (RBCs) Anucleate ~ 5 million/μl Hemoglobin Spectrin High SA/Volume Ratio 5 billion/ml Spectrin is a cytoskeletal protein. In RBCs it acts as a elastic molecule RBCs can taco Note: birds and reptile RBCs have nuclei

Hemoglobin 14-20g/100mls 4 Subunits (globins) Heme group: Fe We will cover hemoglobin more during the respiration unit

Hemoglobin Function Deoxyhemoglobin Oxyhemoglobin Carbaminoglobin CO binds to hemoglobin about 200x more efficiently than O2

RBC Formation Hematopoiesis-blood cell formation Red marrow Sinusoidal Capillaries 100-200bil/day

Blood Cell Lineage Hemocytoblast Potency Committed cells Lineage- family tree Potency- measure of how many different types of cells and arise form a particular cell Totipotent- can make all cells, even extra embryonic tissue Pleuripotent- can make all cells of the body Multipotent- can make all or most of the cells in a tissue type Unipotent- can make only a single type of cell Committed cells- point at which a particular cell is committed to its fate (usually used to discuss when a cell is multipotent) Cell fate- process of a cell committing to a particular pathway