Pere Colls, Ph. D. , Tomas Escudero, M. Sc. , Natalie Cekleniak, M. D

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Presentation transcript:

Increased efficiency of preimplantation genetic diagnosis for infertility using “no result rescue” Pere Colls, Ph.D., Tomas Escudero, M.Sc., Natalie Cekleniak, M.D., Sasha Sadowy, M.Sc., Jacques Cohen, Ph.D., Santiago Munné, Ph.D. Fertility and Sterility Volume 88, Issue 1, Pages 53-61 (July 2007) DOI: 10.1016/j.fertnstert.2006.11.099 Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Nucleus showing a single large signal for chromosome 16 (Aqua Vysis) in regular first FISH panel. Colls. Increased efficiency of preimplantation genetic diagnosis. Fertil Steril 2007. Fertility and Sterility 2007 88, 53-61DOI: (10.1016/j.fertnstert.2006.11.099) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Nucleus showing a split signal for chromosome 15 (Orange Vysis) in regular second FISH panel. Colls. Increased efficiency of preimplantation genetic diagnosis. Fertil Steril 2007. Fertility and Sterility 2007 88, 53-61DOI: (10.1016/j.fertnstert.2006.11.099) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 Nucleus showing a split signal for chromosome 13 (Red Vysis) in regular first FISH panel. Colls. Increased efficiency of preimplantation genetic diagnosis. Fertil Steril 2007. Fertility and Sterility 2007 88, 53-61DOI: (10.1016/j.fertnstert.2006.11.099) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 4 Same nucleus as in Figure 1 reanalyzed with Telomeric 16q (Orange Vysis) as third panel showing two signals for chromosome 16. Colls. Increased efficiency of preimplantation genetic diagnosis. Fertil Steril 2007. Fertility and Sterility 2007 88, 53-61DOI: (10.1016/j.fertnstert.2006.11.099) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 5 Same nucleus as in Figure 2 reanalyzed with LSI 15 (Orange Vysis) as third panel showing two signals for chromosome 15. Colls. Increased efficiency of preimplantation genetic diagnosis. Fertil Steril 2007. Fertility and Sterility 2007 88, 53-61DOI: (10.1016/j.fertnstert.2006.11.099) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 6 Same nucleus as in Figure 3 reanalyzed with LSI 13q34 (Green Vysis) as third panel showing two signals for chromosome 13. Colls. Increased efficiency of preimplantation genetic diagnosis. Fertil Steril 2007. Fertility and Sterility 2007 88, 53-61DOI: (10.1016/j.fertnstert.2006.11.099) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions