Volume 12, Pages (October 2016)

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Volume 12, Pages 239-246 (October 2016) Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality André Scherag, Franziska Schöneweck, Miriam Kesselmeier, Stefan Taudien, Matthias Platzer, Marius Felder, Christoph Sponholz, Anna Rautanen, Adrian V.S. Hill, Charles J. Hinds, Hamid Hossain, Norbert Suttorp, Oliver Kurzai, Hortense Slevogt, Evangelos J. Giamarellos-Bourboulis, Apostolos Armaganidis, Evelyn Trips, Markus Scholz, Frank M. Brunkhorst EBioMedicine Volume 12, Pages 239-246 (October 2016) DOI: 10.1016/j.ebiom.2016.08.043 Copyright © 2016 The Authors Terms and Conditions

Fig. 1 Discovery GWAS: a) Manhattan plot for the analysis of 28day mortality in patients with treated sepsis (additive genetic model). The blue line represents the significance level for a suggestive association signal (i.e. p≤1×10−5) and the red line is the level for a genome-wide association signal (i.e. p≤5×10−8). b) Quantile–quantile (Q–Q) plot of all the GWAS p-values (λ=1.0079) from the analysis of 28day mortality in patients with treated sepsis (additive genetic model). EBioMedicine 2016 12, 239-246DOI: (10.1016/j.ebiom.2016.08.043) Copyright © 2016 The Authors Terms and Conditions

Fig. 2 Regional association plot for a) the chromosome 9q21.2 locus (centered around the lead SNP rs117983287) and b) the chromosome 16 locus (centered around the lead SNP rs2641697) in the analysis of 28day mortality in patients with treated severe sepsis/septic shock (additive genetic model). Colors indicate the correlation (r2 in 1000 Genomes data for Utah residents with northern or western European ancestry (CEU); phase 1, version 3) with the alleles of rs117983287/rs2641697. EBioMedicine 2016 12, 239-246DOI: (10.1016/j.ebiom.2016.08.043) Copyright © 2016 The Authors Terms and Conditions