CatView Ltd Disposable View Catheter Moshe Refael CEO

Contents The technology platform The product Development roadmap Regulatory pathway Investment sought.

Key Personal The Entrepreneurs: Moshe Refael – CEO Prof. Steve Lipson. Optics, Technion Haifa Prof. Ariel Roguin. MD, Rambam Hospital Haifa Dr. Yaron Hefetz Optics, GE Haifa Avinoam Baruch, Mech. Eng.

Current Endoscopy Methods Regular metal pipe line guides NO Viewing guides available on the market (not created.. yet)

The problem Part 1 There are 4 major problems: Light scattering by blood cells. Optical absorption by plasma To provide an image using a few optical fibers. To introduce a stent in the right position

The solution The planned catheter guide To have a channel for introducing a clear liquid in front of the camera, in order to clear the red blood cells and improve the transparency

The solution To provide a viewing guide which allows placement of the stent in the optimum position.

The angiographic beauty of stenting The regular procedure The angiographic beauty of stenting

Stent Placement Guide Balloon Stent

CatView Product The Solution: * To develop a guide with real-time visual observation capabilities, with or without a working channel. * Following this, surgeons will be able to conduct their guides in real time as in gastroscopy.

The Technology Platform The project will create a platform for minimal invasive treatment such as: Heart Catheterized procedures Anaesthetization. Lungs – Bronchoscopy. Urology – in-vivo observation and biopsy Brain blood vessel inspection and treatment

CatView’s Catheter Features Camera creating 80 pixel image Optical fiber bundle with 100 fibers, outer diameter 250µm, for illumination and imaging Nozzle to introduce a clear physiological fluid in front of the imaging lens Navigation drive ---------------------------------------------- Total 325± 25 µm diameter

The calculation is as follows: Optic Calculation Requirements The calculation is as follows: The required resolution according to the MD’s is 500µm The cross-sectional area of the artery is: 4=15.5mm2 Image is projected onto 100 optical fibers Four fibers used for illumination

Fluid injection Annular space around the fiber optic to transport clear fluid to the imaging region Pump to introduce the fluid

Product Overview The Diastolic Head The Intracorpus probe Proximate Joystick Light source Liquid Pump Proximate Interface USB Interface

Front end- Probe Lens Liquid spraying nozzles Navigating head

Probe’s Cross\cut section Fiber Optic Bundle Vacuum & pressure tubular + SPRED LIQUIDS

Cross Cut section 2

Navigator system

Probe’s cross section Fiber Optic bundle Vacuum liquid nozzle Transparent liquid pipe Fiber Optic bundle Vacuum liquid nozzle

Proximate Unit Liquids pipe Optic fiber Lens Beam Splitter Reflected Image Light source CMOS Camera Camera Board

Activities Technological: Detailed design study. Management: Breadboard system Testing Management: Market search & Business Plan Patent search & PCT filing. Helsinki Approval Marketing (for raising money) Preliminary experiments on animals Regulatory strategy FDA path (Human experiments – 3rd year) Technical writing

Gantt R &D Activities 2016 2017 2018 Characterizing Optical design Mechanical design Purchasing* Building of first model Lab test first round Re-design after test improvement Business Plan Strategic regulation Helsinky certification Animal trails FDA approval Human trails Marketing** Money In 500$ K $1.5M $ 4M * Fibers, Camera board, Beam splitter, pump, Joystick ** marketing = Raising money

Thank you