Volume 63, Issue 4, Pages (April 2003)

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Volume 63, Issue 4, Pages 1433-1442 (April 2003) Vitamin C improves resistance but not conduit artery endothelial function in patients with chronic renal failure Jenny M. Cross, Ann E. Donald, Sarah L. Nuttall, John E. Deanfield, Robin G. Woolfson, Raymond J. Macallister Kidney International Volume 63, Issue 4, Pages 1433-1442 (April 2003) DOI: 10.1046/j.1523-1755.2003.00852.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 The effect of intra-arterial infusion of vitamin C on vascular function in subjects with predialysis renal failure. Resistance vessel responses to the endothelium-dependent dilator acetylcholine (A), endothelium-independent dilators glyceryltrinitrate (GTN) (B), and sodium nitroprusside (SNP) (C). Symbols are (○) before vitamin C; (•) after vitamin C. Kidney International 2003 63, 1433-1442DOI: (10.1046/j.1523-1755.2003.00852.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 The effect of vitamin C on vascular function in healthy volunteers. (A) The effect of intra-arterial vitamin C on resistance vessel responses to the endothelium dependent-dilator acetylcholine (ACh). Symbols are (•) before vitamin C; (○) after vitamin C. (B) The effect of intra-arterial vitamin C on the endothelium independent-dilator glyceryltrinitrate (GTN). Symbols are (○) before vitamin C; (•) after vitamin C. Kidney International 2003 63, 1433-1442DOI: (10.1046/j.1523-1755.2003.00852.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3 The effect of intra-arterial NGmonomethyl-L-arginine (L-NMMA) on the augmented dilator response to acetylcholine (ACh) in the presence of vitamin C. Symbols are: (○), Acetylcholine; (•) L-NMMA; (▿) L-NMMA and vitamin C. Kidney International 2003 63, 1433-1442DOI: (10.1046/j.1523-1755.2003.00852.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 4 The effect of intra-arterial vitamin C on conduit artery endothelial function in predialysis renal failure. (A) The velocity time integral (VTI) before (•) and after (○) intra-arterial vitamin C infusion. (B) Radial flow-mediated dilatation (FMD) and dilatation to the endothelium independent dilator, glyceryltrinitrate (GTN). (C) The profile of radial FMD for the 5-minute period after cuff release. Symbols are (○) before vitamin C; (•) after vitamin C. Kidney International 2003 63, 1433-1442DOI: (10.1046/j.1523-1755.2003.00852.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 5 The effect of intravenous vitamin C on conduit artery endothelial function in dialysis dependent renal failure. (A) The velocity time integral (VTI) before (•) and after (○) intravenous vitamin C. (B) The velocity time integral (VTI) before (•) and after (○) intravenous placebo. (C) The effect of intravenous vitamin C on brachial flow-mediated dilatation (FMD). (D) The profile of brachial FMD for the 5-minute period after cuff release is shown before (○) and after (•) vitamin C. (E) The profile of brachial FMD for the 5-minute period after cuff release is shown before (○) and after (•) placebo. (F) ilatation to glyceryltrinitrate (GTN). Kidney International 2003 63, 1433-1442DOI: (10.1046/j.1523-1755.2003.00852.x) Copyright © 2003 International Society of Nephrology Terms and Conditions