Necdin–E2F4 interaction provides insulin-sensitizing effect after weight loss induced by gastric bypass surgery Zehra N. Pamuklar, M.D., Ph.D., Jiegen.

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Necdin–E2F4 interaction provides insulin-sensitizing effect after weight loss induced by gastric bypass surgery Zehra N. Pamuklar, M.D., Ph.D., Jiegen Chen, Ph.D., Michael Muehlbauer, Ph.D., Anna Spagnoli, M.D., Alfonso Torquati, M.D., M.S.C.I. Surgery for Obesity and Related Diseases Volume 9, Issue 1, Pages 94-99 (January 2013) DOI: 10.1016/j.soard.2011.10.014 Copyright © 2013 American Society for Metabolic and Bariatric Surgery Terms and Conditions

Fig. 1 Free IGF-1 levels determined in plasma collected from obese patients (Obese), patients ≥12 months after RYGB, and nonobese controls (Lean). Data presented as mean ± SD. Surgery for Obesity and Related Diseases 2013 9, 94-99DOI: (10.1016/j.soard.2011.10.014) Copyright © 2013 American Society for Metabolic and Bariatric Surgery Terms and Conditions

Fig. 2 Relative necdin and E2F4 RNA levels normalized to glyceraldehyde 3-phosphate dehydrogenase RNA levels in subcutaneous and omental adipose tissue collected from obese patients, patients ≥12 months after RYGB, and nonobese controls. Data presented as mean ± SEM. *P < .05 versus obese; **P < .01 versus obese. Surgery for Obesity and Related Diseases 2013 9, 94-99DOI: (10.1016/j.soard.2011.10.014) Copyright © 2013 American Society for Metabolic and Bariatric Surgery Terms and Conditions

Fig. 3 Effect of des-IGF-1 on necdin and E2F4 gene expression in cultured adipocytes. Data presented as mean ± SEM. *P < .05 versus control; **P < .01 versus control. Surgery for Obesity and Related Diseases 2013 9, 94-99DOI: (10.1016/j.soard.2011.10.014) Copyright © 2013 American Society for Metabolic and Bariatric Surgery Terms and Conditions