Reduced Level of CD44 and Hyaluronan Associated with Unfavorable Prognosis in Clinical Stage I Cutaneous Melanoma Jari M. Karjalainen, Raija H. Tammi,

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Reduced Level of CD44 and Hyaluronan Associated with Unfavorable Prognosis in Clinical Stage I Cutaneous Melanoma Jari M. Karjalainen, Raija H. Tammi, Markku I. Tammi, Matti J. Eskelinen, Ulla M. Ågren, Jyrki J. Parkkinen, Esko M. Alhava, Veli-Matti Kosma The American Journal of Pathology Volume 157, Issue 3, Pages 957-965 (September 2000) DOI: 10.1016/S0002-9440(10)64608-1 Copyright © 2000 American Society for Investigative Pathology Terms and Conditions

Figure 1 HA (A, C, E) and CD44 (B, D) stainings of cutaneous melanoma. A: Left, HA-positive tumor. Note HA-positive dermal stroma (asterisk). Right, a cons3ecutive section digested by Streptomyces hyaluronidase before HA staining (negative control). Scale bar, 100 μm. B and C: Consecutive sections, strong CD44 and HA positivity. Asterisk, epidermis. Scale bars, 100 μm. D and E: Consecutive sections without cell surface CD44 or cellular HA signal. Tumor stroma (arrows) is HA positive. Scale bars, 50 μm. The American Journal of Pathology 2000 157, 957-965DOI: (10.1016/S0002-9440(10)64608-1) Copyright © 2000 American Society for Investigative Pathology Terms and Conditions

Figure 2 Distributions of the cutaneous melanomas according to the percentage of CD44 (A) and HA (B) positivity among the malignant cells (n = 282 for CD44 and 277 for HA). The American Journal of Pathology 2000 157, 957-965DOI: (10.1016/S0002-9440(10)64608-1) Copyright © 2000 American Society for Investigative Pathology Terms and Conditions

Figure 3 A: OS according to cell surface CD44 expression. N = 282. B: OS according to tumor cell associated HA expression. N = 277. The American Journal of Pathology 2000 157, 957-965DOI: (10.1016/S0002-9440(10)64608-1) Copyright © 2000 American Society for Investigative Pathology Terms and Conditions

Figure 4 A: RFS according to cell surface CD44 expression. N = 282. B: RFS according to tumor cell associated HA expression. N = 277. The American Journal of Pathology 2000 157, 957-965DOI: (10.1016/S0002-9440(10)64608-1) Copyright © 2000 American Society for Investigative Pathology Terms and Conditions