Treatment of Stage I and II Non-small Cell Lung Cancer

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Treatment of Stage I and II Non-small Cell Lung Cancer John A. Howington, MD, FCCP, Matthew G. Blum, MD, FCCP, Andrew C. Chang, MD, FCCP, Alex A. Balekian, MD, MSHS, Sudish C. Murthy, MD, PhD, FCCP CHEST Volume 143, Issue 5, Pages e278S-e313S (May 2013) DOI: 10.1378/chest.12-2359 Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 1 Outcomes of surgical resection for lung cancer according to specialization. CHEST 2013 143, e278S-e313SDOI: (10.1378/chest.12-2359) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 2 Outcomes of surgical resection for lung cancer according to case volume. CHEST 2013 143, e278S-e313SDOI: (10.1378/chest.12-2359) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 3 [Section 2.2.2] Meta-analysis of relationship between outcomes and hospital case volume of lung cancer resections. A, Perioperative mortality. B, Long-term survival. Higher Limit = lowest annual volume in the high-volume category; lower limit = highest annual volume in the lower limit category. (Reproduced with permission from von Meyenfeldt et al.12) CHEST 2013 143, e278S-e313SDOI: (10.1378/chest.12-2359) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 4 Outcomes of surgical resection for lung cancer according to teaching facility status. CHEST 2013 143, e278S-e313SDOI: (10.1378/chest.12-2359) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 5 [Section 3.1] Outcomes of thoracoscopic vs open lung cancer resection. Results of a meta-analysis of comparative studies. Most of the included studies were cohort studies, not randomized studies. A, Perioperative outcomes. B. Long-term outcomes. Card = cardiac; Compl = complication; F/U = follow-up; Hosp LOS = hospital length of stay; Periop = perioperative; Pulm = pulmonary; rand = randomized studies; Resp dysfctn = respiratory dysfunction; S at max f/u = survival at maximal follow-up; Surv = survival; VATS = video-assisted thoracic surgery. (Data from Cheng et al.50 Figures reproduced with permission from Detterbeck.51) CHEST 2013 143, e278S-e313SDOI: (10.1378/chest.12-2359) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 6 Comparative outcomes for lobectomy and sublobar resection. CHEST 2013 143, e278S-e313SDOI: (10.1378/chest.12-2359) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 7 Comparative outcomes for wedge resection and segmentectomy. CHEST 2013 143, e278S-e313SDOI: (10.1378/chest.12-2359) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 8 Primary tumor control and survival following SBRT for clinical stage I NSCLC. CHEST 2013 143, e278S-e313SDOI: (10.1378/chest.12-2359) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 9 Primary tumor control and survival following RFA for clinical stage I NSCLC. CHEST 2013 143, e278S-e313SDOI: (10.1378/chest.12-2359) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 10 Outcomes of adjuvant chemotherapy after surgical resection. CHEST 2013 143, e278S-e313SDOI: (10.1378/chest.12-2359) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 11 [Section 6.1.2] Meta-analysis of effect of postoperative chemotherapy on overall survival. A, Effect of traditional cytotoxic chemotherapy. B, Effect of uracil/tegafur chemotherapy. Exploratory analyses of the effect of surgery and chemotherapy vs surgery alone on survival, by use of tegafur plus uracil or tegafur, and by stage and performance status. Overall survival: hazard ratio of death with postoperative chemotherapy vs control (no chemotherapy) by treatment strategy or baseline patient characteristic. PS = performance status. (Reproduced with permission from Pignon et al184 and Arriagada et al.200) CHEST 2013 143, e278S-e313SDOI: (10.1378/chest.12-2359) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 12 [Section 6.2.1] Meta-analysis of postoperative radiotherapy on overall survival. (Reproduced with permission from Burdett et al.214) CHEST 2013 143, e278S-e313SDOI: (10.1378/chest.12-2359) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 13 Outcomes of adjuvant radiotherapy after surgical resection. CHEST 2013 143, e278S-e313SDOI: (10.1378/chest.12-2359) Copyright © 2013 The American College of Chest Physicians Terms and Conditions