Anti-thymocyte Globulin (Rabbit) Drugbank ID : DB00098 Half life : 2-3 days, may increase after multiple doses administration Description : Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells.

Indication : For prevention of renal transplant rejection Pharmacodynamics : Antithymocyte Globulin (ATG) is a concentrated anti-human T-lymphocyte immunoglobulin preparation derived from rabbits after immunization with a T-lympoblast cell line. ATG is an immunosuppressive product for the prevention and treatment of acute rejection following organ transplantation. ATG reduces the host immune response against tissue transplants or organ allografts.

Mechanism of action : Binds to multiple, T-cell specific antigens leading to T-lymphocyte cell death via complement mediated cytotoxicity or apoptosis. Metabolism : Most likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production. Absorption : T-cell depletion usually observed within 1 day after initiating therapy. Average 21.5 and 87 mcg/mL 4–8 hours post-infusion after first and last IV doses, respectively, when given for 7–11 days.

Categories : Antibody Targets :T-cell surface glycoprotein CD1a, Major histocompatibility complex class I-related gene protein, Integrin alpha-L, T-lymphocyte activation antigen CD86, Low affinity immunoglobulin gamma Fc region receptor II-b, T-cell surface glycoprotein CD4, Integrin beta-1, Integrin alpha-V, Integrin beta-3 Brands : ATG-Fresenius Company : Genzyme Inc. Formulation : One ml of the concentrate contains 20 mg anti-human T-lymphocyte immunoglobulin from rabbits Form : Concentrate for solution for infusion. Route of administration : Intravenous

Dosage : One ml of the concentrate contains 20 mg anti-human T-ddiThe recommended dose range is 2 to 5 mg/kg/d ATG - Fresenius S. The most common doses are in the range of 3 to 4 mg/kg/ dlymphocyte immunoglobulin from rabbits Contraindication : Hypersensitivity to the active substance or to any of the excipients Side effects : bladder pain,chest pain,chills

Useful links http://www.pharmaline.co.il/images/newsletterregistration/neopharm/2012/11052012/atgdr.pdf