Immunosuppressives & chemo tutoring Alaina Darby

Immunosuppression

Which of the following describes a cytokine that has the same effect on different cells? Redundancy Synergy Pleiotropy Antagonism c

Which of the following is not true of immunosuppression? The secondary responses are more easily suppressed by immunosuppressives Immunosuppressives are more effective when administered before exposure Immunosuppressives are often used in transplant procedures Immunosupressives with complementary mechanism should be utilized a

Which of the following acts primarily on the effector phase to prevent T cell proliferation? Corticosteroids Sirolimus Cyclosporine Tacrolimus b

Electrolyte imbalance Osteoporosis Over-production of corticosteroids Which of the following is not an adverse effect of glucocorticoid treatment? Electrolyte imbalance Osteoporosis Over-production of corticosteroids GI bleeding c

Which of the following is true of Rhogam? Prevents erythroblastosis fetalis in an Rh- mother and Rh+ fetus Prevents erythroblastosis fetalis in an Rh- mother and Rh- fetus Prevents erythroblastosis fetalis in an Rh+ mother and Rh+ fetus Prevents erythroblastosis fetalis in an Rh+ mother and Rh- fetus a

Which of the following does not bind to FKBP? Tacrolimus Cyclosporine Sirolimus Everolimus b

Which of the following does not bind to calcineurin? Tacrolimus Cyclosporine Sirolimus c

Which of the following is not a macrolide antibiotic? Tacrolimus Cyclosporine Sirolimus Everolimus b

Which of the following is also known as rapamycin? Tacrolimus Cyclosporine Sirolimus Everolimus c

Which of the following can be used prophylactically or acutely for transplant rejection? Glucocorticoids ATG Cyclosporine Sirolimus b

Which of the following exerts its effects in the nucleus by inhibiting activity of NFAT? Glucocorticoids ATG Cyclosporine Sirolimus c

Which of the following inhibits the expression of IL-2 receptors and has no direct effects on B cell production? Glucocorticoids ATG Cyclosporine Sirolimus c

Which of the following exerts its effects by blocking T cell activation through the T cell receptor? Glucocorticoids ATG Cyclosporine Sirolimus b

Which of the following exerts its effects by moving into and binding to DNA elements in the nucleus? Glucocorticoids ATG Cyclosporine Sirolimus a

Which of the following can be used to treat lymphocytic leukemia due to its ability to directly control the expansion of B and T cells? Glucocorticoids ATG Cyclosporine Sirolimus a

Which of the following antibodies is used therapeutically to antagonize IL-2 receptors and to decrease acute kidney allograft rejection? ATG ALG Basiliximab Daclizumab c

Which of the following inhibits TMP synthesis? Pentostatin Hydroxyurea 6-Mercaptopurine 5-Flurouracil d

Which of the following inhibits ribonucleotide reductase? Pentostatin Hydroxyurea 6-Mercaptopurine 5-Flurouracil b

Which of the following inhibits nucleotide interconversions? Pentostatin Hydroxyurea 6-Mercaptopurine 5-Flurouracil c

Which of the following is inhibited by mycophenolate mofetil? Ribonucleotide reductase Dihydrofolate reductase Inosine monophosphate dehydrogenase Adenosine deaminase c

Which of the following is the target of infliximab and etanercept? AKT kinase Dihydroorotate dehydrogenase TNF IL-2 c

Chemotherapy

Which of the following describes carcinogenesis? Cells do not differentiate following genetic mutation Cells undergo altered regulation following genetic mutation Cells continually undergo apoptosis following differentiation Cells adhere to strict mechanisms of cell division and differentiation b

Which of the following is not true of cancer? It more prevalent in old age due to accumulation of mutations It is a single disease characterized by unrestricted cell growth It may involve abnormal regulation of the cell cycle It is dependent upon the mutation of proto-oncogenes b

Which of the following is not a path that stem cells might take? Division into more stem cells when proliferation when more cells are needed Dormancy when additional cells are not necessary Differentiation into cells that are less specific to that tissue type Death of the cell when there are more stem cells than are needed c

Terminally differentiated cells Embryonal stem cells Which of the following types of cells may differentiate into the widest variety of cell types? Adult stem cells Terminally differentiated cells Embryonal stem cells Lineage stem cells c

Which of the following occurs at the G1 phase in mitosis? Gene replication Cell division Check that DNA is replicated Direction on which path the cell should take d