AOC Surgical Outcome Survey Characteristic Onc. Ref. Centres Other p Patients 140 65 Age: median (range) 60 (32-85) 59 (45-77) 0.16 PS: median (range) 1 (0.3) 1 (0-3) 0.85 ASA: median (range) 2 (1-4) 2 (1-3) 0.89 Preop. CA125: median (range) 727 (10-13.641) 690 (32-12.356) 0.88 Ascites: median (range) 2000 (50-10.000) 2000 (100-11.000) Histology: serous 98 (70.0) 50 (76.9) 0.32 Grade: poor 103 (73.6) 53 (81.5) 0.29 FIGO Stage: IIIC + IV 126 (90) 62 (95.4) 0.27 Bulky nodes 41 (29.3) 13 (20) 0.17

AOC Surgical Outcome Survey Scores by Pattern of Centre Onc. Ref. Centres Other p Patients 140 65 Perit. Ca. Index: mean (range) 17.2 (3-33) 15.4 (4-39) 0,79 Eisenkop S.: mean (range) 8.5 (2-15) 7.8 (2-13) 0,20 Fagotti S.: mean (range) 7.5 (0-14) 7.3 (0-14) 0.79

AOC Surgical Outcome Survey CC by Pattern of Centre Completeness of surgical cytoreduction Onc. Ref. Centres Other p Patients 140 65 CC=0 84 (60) 16 (24.6) <0,001 CC=1 18 (2.9) 7 (10.8) CC=2 9 (6.4) 21 (32.3) CC=3 29 (20.7)

AOC Surgical Outcome Survey Multivariate Analysis of CC=0 Variable Multivariate Analysis p OR (95% CI) ASA: 1-2 1 <0.05 3-4 2.98 (1.34-6.64) Peritoneal Cancer Index: < 20 > 20 4.29 (1.82-10.08) Eisenkop Score: <6 <0.001 >6 13.37 (3.81-46.93) Centre: Oncol. Referral Centre Other 11,97 (4,66-30,76)

AOC Surgical Outcome Survey Causes of CC=2-3 by Pattern of Centre .1 Cause of unsuccessful surgical cytoreduction Onc. Ref. Centres (N=38) Other (N=41) p Tumor dependent 32 (84.2) 7 (17.1) <0.001 Diffuse peritoneal carcinomatosis 24 (63.2) > 3 bowel resection required 1 (2.6) Infiltration of porta hepatis Bulky N over the renal vessels 3 (7.9) Infiltration of mesenter basis

AOC Surgical Outcome Survey Causes of CC=2-3 by Pattern of Centre .2 Cause of unsuccessful surgical cytoreduction Onc. Ref. Centres (N=38) Other (N=41) p Surgeon dependent 6 (15.8) 34 (82.9) <0.001 No or inadeguate additional surgery Diaphragm 3 (7.9) 14 (34.1) Diaphragm + RP 4 (9.8) Pelvis 2 (5.3) 5 (12.2) Pelvis + RP 2 (4.9) Diaphragm + pelvis 1 (2.6) 9 (22)