Phenotype expression in familial combined hyperlipidemia

Slides:

Advertisements

Similar presentations

Loss of Pax5 Promotes Plasma Cell Differentiation Kalle-Pekka Nera, Pekka Kohonen, Elli Narvi, Anne Peippo, Laura Mustonen, Perttu Terho, Kimmo Koskela,

Advertisements

The Genome-wide Patterns of Variation Expose Significant Substructure in a Founder Population Eveliina Jakkula, Karola Rehnström, Teppo Varilo, Olli P.H.

Positionally Cloned Gene for a Novel Glomerular Protein—Nephrin—Is Mutated in Congenital Nephrotic Syndrome Marjo Kestilä, Ulla Lenkkeri, Minna Männikkö,

Cultured Schwann Cells Constitutively Express the Myelin Protein P0 Lili Cheng, Anne W Mudge Neuron Volume 16, Issue 2, Pages (February 1996) DOI:

Life-time risk factors and progression of carotid atherosclerosis in young adults: the Cardiovascular Risk in Young Finns study by Markus Juonala, Jorma.

Effects of plant stanol esters on serum cholesterol concentrations, relative markers of cholesterol metabolism and endothelial function in type 1 diabetes

Early childhood hospitalisation with infection and subclinical atherosclerosis in adulthood: The Cardiovascular Risk in Young Finns Study David P. Burgner,

How well does the metabolic syndrome defined by five definitions predict incident diabetes and incident coronary heart disease in a Chinese population?

The Association of Dietary Alpha-Linolenic Acid with Blood Pressure and Subclinical Atherosclerosis in People Born Small for Gestational Age: The Special.

Genomewide Scan for Familial Combined Hyperlipidemia Genes in Finnish Families, Suggesting Multiple Susceptibility Loci Influencing Triglyceride, Cholesterol,

Effect of age, gender and cardiovascular risk factors on carotid distensibility during 6- year follow-up. The cardiovascular risk in Young Finns study

Short-term heart rate variability in healthy young adults

Volume 167, Issue 2, Pages (April 2003)

A longitudinal analysis on associations of adiponectin levels with metabolic syndrome and carotid artery intima-media thickness. The Cardiovascular Risk.

Volume 376, Issue 9750, Pages (October 2010)

Association of Adiponectin with Adolescent Cardiovascular Health in a Dietary Intervention Study Johanna M. Jaakkola, PhD, Katja Pahkala, PhD, Marika.

Relation of total and free testosterone and sex hormone-binding globulin with cardiovascular risk factors in men aged 24–45 years. The Cardiovascular.

Apolipoprotein B is related to arterial pulse wave velocity in young adults: The Cardiovascular Risk in Young Finns Study Teemu Koivistoinen, Nina Hutri-Kähönen,

Early childhood hospitalisation with infection and subclinical atherosclerosis in adulthood: The Cardiovascular Risk in Young Finns Study David P. Burgner,

Volume 164, Issue 2, Pages (October 2002)

Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors Ari V. Ahola-Olli, Peter Würtz,

Quantitative-Trait-Locus Analysis of Body-Mass Index and of Stature, by Combined Analysis of Genome Scans of Five Finnish Study Groups Markus Perola,

Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow- mediated dilation and carotid artery distensibility: The Cardiovascular.

Body-image dissatisfaction is strongly associated with chronic dysphoria Tom Rosenström, Markus Jokela, Mirka Hintsanen, Kim Josefsson, Markus Juonala,

Volume 154, Issue 2, Pages (February 2001)

Adult dyslipidemia prediction is improved by repeated measurements in childhood and young adulthood. The Cardiovascular Risk in Young Finns Study Joel.

Improved cardiovascular outcomes following temporal advances in lipid-lowering therapy in a genetically-characterised cohort of familial hypercholesterolaemia.

Volume 145, Issue 2, Pages (August 1999)

Two Loci on Chromosomes 2 and X for Premature Coronary Heart Disease Identified in Early- and Late-Settlement Populations of Finland Päivi Pajukanta,

Olli T. Raitakari, Ville-Petteri Mäkinen, Matthew J

A randomised clinical trial of routine versus selective CT imaging in acute abdomen: Impact of patient age on treatment costs and hospital resource use

Interleukin-18 promoter polymorphism associates with the occurrence of sudden cardiac death among Caucasian males: The Helsinki Sudden Death Study Jussi.

Effect of age, gender and cardiovascular risk factors on carotid distensibility during 6- year follow-up. The cardiovascular risk in Young Finns study

Proinflammatory HLA-DRB1

Serum complement and familial combined hyperlipidemia

Volume 151, Issue 2, Pages (August 2000)

Apolipoprotein A-I/C-III/A-IV SstI and apolipoprotein B XbaI polymorphisms and their association with carotid artery intima-media thickness in the Finnish.

Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: Results of a 24week, double-blind, randomized.

Warm-up September 21, 2017 (-5) – 6 = 5 – (-6) = (-5) + 6 =

KDIGO Clinical Practice Guideline for Lipid Management in CKD: summary of recommendation statements and clinical approach to the patient Christoph Wanner,

Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and.

Bettina Haslinger-Löffler Kidney International

In and Out: Adipose Tissue Lipid Turnover in Obesity and Dyslipidemia

Volume 376, Issue 9750, Pages (October 2010)

Genomewide Scan for Familial Combined Hyperlipidemia Genes in Finnish Families, Suggesting Multiple Susceptibility Loci Influencing Triglyceride, Cholesterol,

Volume 1, Issue 4, Pages (October 2015)

J. W. Balder, MD, PhD, P. J. Lansberg, MD, PhD, M. H. Hof, MSc, A

Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors Ari V. Ahola-Olli, Peter Würtz,

Gain-of-Function Lipoprotein Lipase Variant rs13702 Modulates Lipid Traits through Disruption of a MicroRNA-410 Seed Site Kris Richardson, Jennifer A.

Marina Cuchel, Dirk J. Blom, Maurizio R. Averna

Lysosomal acid lipase deficiency: A hidden disease among cohorts of familial hypercholesterolemia? Joana Rita Chora, MSc, Ana Catarina Alves, PhD, Ana.

Mikko Syvänne, MD, Marja-Riitta Taskinen, MD The Lancet

Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: Results of a 24week, double-blind, randomized.

Hajer GR et al. Atherosclerosis 2009;202:216-24

Manuela Casula, Alberico L

Volume 376, Issue 9750, Pages (October 2010)

Volume 130, Issue 6, (September 2007)

Combined Analysis of Genome Scans of Dutch and Finnish Families Reveals a Susceptibility Locus for High-Density Lipoprotein Cholesterol on Chromosome.

Recommendations for the management of patients with homozygous familial hypercholesterolaemia: Overview of a new European Atherosclerosis Society consensus.

In and Out: Adipose Tissue Lipid Turnover in Obesity and Dyslipidemia

Neighbourhood socioeconomic disadvantage, risk factors, and diabetes from childhood to middle age in the Young Finns Study: a cohort study Prof Mika.

Two Loci on Chromosomes 2 and X for Premature Coronary Heart Disease Identified in Early- and Late-Settlement Populations of Finland Päivi Pajukanta,

Recurrence of Marfan Syndrome as a Result of Parental Germ-Line Mosaicism for an FBN1 Mutation Terhi Rantamäki, Ilkka Kaitila, Ann-Christine Syvänen,

Evaluating the Quality of Dying and Death

Comparison of GenFlex Tag Array and Pyrosequencing in SNP Genotyping

Position of the American Dietetic Association

Volume 65, Issue 5, Pages (May 2004)

Comparison of 2 Acute Renal Failure Severity Scores to General Scoring Systems in the Critically Ill Annika Åhlström, MD, Anne Kuitunen, MD, PhD, Seija.

Volume 134, Issue 6, (September 2008)

SEPTEMBER 2019 ISSUE/42 nd VOLUME.

Presentation transcript:

Phenotype expression in familial combined hyperlipidemia Kimmo V.K Porkka, Ilpo Nuotio, Päivi Pajukanta, Christian Ehnholm, Leena Suurinkeroinen, Mikko Syvänne, Terho Lehtimäki, Anne- Tiina Lahdenkari, Sanni Lahdenperä, Kati Ylitalo, Marjatta Antikainen, Markus Perola, Olli T Raitakari, Petri Kovanen, Jorma S.A Viikari, Leena Peltonen, Marja-Riitta Taskinen Atherosclerosis Volume 133, Issue 2, Pages 245-253 (September 1997) DOI: 10.1016/S0021-9150(97)00134-2

Fig. 1 Influence of percentile cut-point used for lipid criteria (total cholesterol and triglycerides) on the fraction of affected versus not affected FCHL family members. Data is presented for the second generation only. Atherosclerosis 1997 133, 245-253DOI: (10.1016/S0021-9150(97)00134-2)