CERAD immediate memory verbal fluency (animals) Migraine and Cognitive Function: baseline Findings From the Brazilian Longitudinal Study of Adult Health - ELSABrasil Cristina Pellegrino Baena, Alessandra Carvalho Goulart, Paulo Andrade Lotufo, Itamar de Souza Santos, Isabela Martins Benseñor Universidade de Sao Paulo USP; Pontificia Universidade Católica do Paraná PUCPR BACKGROUND Migraine and dementia are associated with higher vascular risk and both conditions have been linked with structural brain lesions Evidence on the possible association between migraine and cognitive performance is unclear. AIM To analyze whether migraine is associated with cognitive performance within the Brazilian Longitudinal Study of Adult Health, ELSA-Brasil. METHODS Cross-sectional analysis All participants without previous stroke, who were not taking medications that could impair cognitive performance and with complete data on cognitive tests or migraine at baseline assessment were analyzed Migraine based on International Headache Society classification was used as dependent variable in binary logistic models The Consortium to Establish a Registry for Alzheimer’s disease scores for word list memory test (CERAD-WLMT), the semantic fluency test (SFT), and the Trail Making Test version B (TMTB) were categorized into poor cognitive performance as defined by a score below mean minus one standard deviation for a participant’s sex, age and educational-level group for memory and fluency tests and as a score above mean plus one standard deviation for the time to perform the Trail Making Test Version B Multivariate analyses were adjusted for marital status, alcohol consumption, smoking, physical activity, body-mass index, hypertension, diabetes mellitus and depression. In women we further adjusted for hormone replacement therapy. RESULTS 4993 men(51.6 ±9.2 y) and 5028 women (51.9±8.9y ) were analyzed 131 men( 2.6 %) and 926 women (18.4%) migraneurs Proportion of participants in the poor cognitive category did not differ significantly between migraneurs and non-migraneurs for men or women in any of the cognitive tests (p>0.072 for all) Table 1 - Characteristics of the studied population (n=10023; men=4993; women n = 5030)     Men (n=4993) Women n=(5030) p-value Non-migraineurs Migraineurs n= 4862 n=131 n=4104 n=926 Age (sd) 51.73 (9.3) 48.4 (6.6) p<0.001 52.81 (9.0) 48.1 (7.3) Race (%) 0.289 0.127 White 2695 (56.2) 63 (49.2) 2230 (54.9) 481 (52.2) Brown 1371 (28.6) 40 (31.3) 1018 (25.1) 242 (26.2) Black 596 (12.4) 19 (14.8) 645 (15.9) 170 (18.4) Educational level (%) 0.056 High school 1615 (33.2) 58 (44.3) 1323 (32.3) 379 (40.9) College or higher 2750 (56.6) 61 (46.6) 2543 (62) 498 (53.8) Marital status (%) 0.100 0.001 Married 2991 (61.5) 81 (61.8) 1555 (37.9) 384 (41.5) Not married, but live with other 964 (19.8) 23 (17.6) 553 (13.5) 155 (16.7) BMI kg/m2 (sd) 27.05 (4.26) 25.95 (4.27) 0.004 26.90 (5.12) 26.72 (5.01) 0.323 Smoking status (%) 0.620 0.333 Never 2500 (51.4) 73 (55.7) 2568 (62.6) 583 (63) Former 1696 (34.9) 42 (32.1) 1083 (26.4) 228 (24.6) Current 666 (13.7) 16 (12.2) 453 (11) 115 (12.4) Alcohol use (%) 203 (4.2) 11 (8.4) 580 (14.1) 144 (15.6) 780 (16) 38 (29) 715 (17.4) 211 (22.8) 3878 (79.8) 82 (62.6) 2805 (68.4) 571 (61.7) Physical activity (%) 0.299 Weak 3418 (71.3) 99 (77.3) 3115 (77.1) 749 (82.6) Moderate 789 (16.5) 18 (14.1) 566 (14) 101 (11.1) Vigorous 585 (12.2) 11 (8.6) 359 (8.9) 57 (6.3) Depression (%) 76 (1.6) 7 (5.3) 0.006 125 (3) 83 (9) High blood pressure (%) 1889 (38.9) 31 (23.7) 1290 (31.4) 214 (23.1) Diabetes mellitus (%) 1070 (22) 0.007 681 (16.6) 112 (12.1) Dyslipidemia (%) 2879 (59.2) 176 (58) 0.376 2349 (57.3) 494 (53.3) 0.033 HRT$ (%) 436 (10.6) 69 (7.5) 0.537 Table 2- Odds ratio (95% confidence interval) of poor cognitive performance in migraineurs compared to non-migraineurs. migraineurs versus non-migraineurs   CERAD immediate memory CERAD recall memory CERAD recognition verbal fluency (animals) Trail B making test Men Model 1 1.01 (0.61;1.67) 1.17 (0.72;1.91) 0.83 (0.51;1.36) 1.13 (0.68;1.90) 1.70 (0.93;3.10) Model 2 1.00 (0.60;1.66) 1.11 (0.68;1.83) 0.84 (0.51;1.38) 1.13 (0.67;1.89) 1.72 (0.94;3.14) Women 0.84 (0.69;1.01) 1.01 (0.84;1.22) 1.19 (0.96;1.46) 1.02 (0.83;1.26) 1.07 (0.87;1.32) 0.86 (0.70;1.05) 1.03 (0.85;1.24) 1.20 (0.97;1.48) 0.97 (0.78;1.20) 1.04 (0.85;1.29) Model 3 0.85 (0.70;1.04) 1.02 (0.85;1.24) 1.19 (0.96;1.47) 0.97 (0.79;1.21) 1.05 (0.85;1.29) Model 1 - age and education adjusted, Model 2 - plus marital status, alcohol consumption, smoking, physical activity, BMI, high blood pressure, diabetes mellitus and depression. Model 3 - plus hormonal replacement therapy Figure 2 – Proportion (%) of participants in the poor performance category for each cognitive scores * by sex. * Mean minus 1 SD for memory and fluency tests and mean plus 1SD for TMTB CONCLUSION Migraine is not associated with cognitive performance in middle-aged participants of the ELSA-study. The authors have no disclosure to make. Contact: isabensenor@gmail.com