Association between the diagnosis-to-treatment interval and overall survival in Taiwanese patients with oral cavity squamous cell carcinoma Chun-Ta Liao,

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Association between the diagnosis-to-treatment interval and overall survival in Taiwanese patients with oral cavity squamous cell carcinoma Chun-Ta Liao, Hsin-Ni Chen, Yu-Wen Wen, Shu Ru Lee, Shu-Hang Ng, Tsang-Wu Liu, Sen-Tien Tsai, Ming-Hsui Tsai, Jin-Ching Lin, Pei-Jen Lou, Cheng Ping Wang, Pen-Yuan Chu, Yi-Shing Leu, Kuo-Yang Tsai, Shyuang-Der Terng, Tsung-Ming Chen, Cheng-Hsu Wang, Chih-Yen Chien, Wen-Cheng Chen, Li-Yu Lee, Chien-Yu Lin, Hung-Ming Wang, Chih-Hung Lin, Tuan-Jen Fang, Shiang-Fu Huang, Chung-Jan Kang, Kai-Ping Chang, Lan Yan Yang, Tzu-Chen Yen European Journal of Cancer Volume 72, Pages 226-234 (February 2017) DOI: 10.1016/j.ejca.2016.11.010 Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 1 Flow of the patients through the study. European Journal of Cancer 2017 72, 226-234DOI: (10.1016/j.ejca.2016.11.010) Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 2 Adjusted hazard ratio (HR) of overall mortality according to the diagnosis-to-treatment interval (DTI). European Journal of Cancer 2017 72, 226-234DOI: (10.1016/j.ejca.2016.11.010) Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 3 A binary recursive partition method was applied to determine the optimal cutoff point for diagnosis-to-treatment interval (DTI) between 21 and 90 days. European Journal of Cancer 2017 72, 226-234DOI: (10.1016/j.ejca.2016.11.010) Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 4 Kaplan–Meier plots of the 5-year overall survival for the 20-day (panel A) and 30-day (panel B) groups. European Journal of Cancer 2017 72, 226-234DOI: (10.1016/j.ejca.2016.11.010) Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 5 Multivariate Cox regression model for overall survival in the 20-day (panel A) and 30-day (panel B) groups. European Journal of Cancer 2017 72, 226-234DOI: (10.1016/j.ejca.2016.11.010) Copyright © 2016 Elsevier Ltd Terms and Conditions

Supplementary Fig. 1 Scatter diagram and regression line showing an inverse relationship between the diagnosis-to-treatment interval and overall survival. European Journal of Cancer 2017 72, 226-234DOI: (10.1016/j.ejca.2016.11.010) Copyright © 2016 Elsevier Ltd Terms and Conditions

Supplementary Fig. 2 Univariate Cox regression model for overall survival in the 20-day group. European Journal of Cancer 2017 72, 226-234DOI: (10.1016/j.ejca.2016.11.010) Copyright © 2016 Elsevier Ltd Terms and Conditions

Supplementary Fig. 3 Kaplan–Meier plots of the 5-year overall survival in the 20-day diagnosis-to-treatment interval (DTI) groups stratified according to age <65 years (panel A) and ≥65 years (panel B). Kaplan–Meier plots of the 5-year overall survival in the 20-day DTI groups stratified according to c-stage I–II (panel C) and c-stage II (panel D). Kaplan–Meier plots of the 5-year overall survival in the 20-day DTI groups stratified according to initial surgery (panel E) and initial non-surgical management (panel F). European Journal of Cancer 2017 72, 226-234DOI: (10.1016/j.ejca.2016.11.010) Copyright © 2016 Elsevier Ltd Terms and Conditions