DCE SMART Team : The Bubonic Plague

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Presentation transcript:

DCE SMART Team 2011-2012: The Bubonic Plague By Zach Peterson and Matt Gargulak Mentor: MSOE CBM Dr. Colton

What is SMART? - Students Modeling A Research Topic - Organize groups - Research the topic - Write an abstract - Use Jmol to recreate biomolecular structure http://upload.wikimedia.org/wikipedia/commons/b/b0/Jmol_logo.jpg

History of the Bubonic Plague - Plague of Justinian (500s) - First recorded epidemic - Black Death (1347) - Major outbreak in Europe - Treatment - Eat well, rest, and leave infected areas - Biological Warfare - 14th century armies used bubonic plague to their advantage

http://upload. wikimedia http://upload.wikimedia.org/wikipedia/commons/1/1b/Bubonic_plague_victims-mass_grave_in_Martigues%2C_France_1720-1721.jpg

Importance of the Bubonic Plague - Common in rats - Transmitted through fleas to humans - Extremely contagious - Fast-acting - Had no cure http://upload.wikimedia.org /wikipedia/commons/d/d0/Y ersinia_pestis.jpghttp://uplo ad.wikimedia.org/wikipedia/ commons/d/d0/Yersinia_pest is.jpg http://upload.wikimedia.org /wikipedia/commons/c/c1/F lea_infected_with_yersinia_p estis.jpg

Surface Protein - Pla - Gram-negative bacteria - Attaches to cell walls in the lymph nodes - Attracts Plasminogen activator inhibitors (PAI) into negative pocket - Breaks peptide bonds http://micro.digitalproteus.com/pics/grambacterium.jpg

Yersinia Pestis (Scientific Name) - Most commonly caused by the bite of an infected rodent or parasite - Rarely transmitted by human contact - Common in unsanitary rural areas - Oftentimes fatal http://www.rkm.com.au/imagelibrary/thumbnails/Yersinia150.jpg

Yersinia Pestis (Scientific Name) - Comes in three forms - Bubonic (Lymphatic) - Pneumonic (Respiratory) - Septicemic (Circulatory) http://s2.hubimg.com/u/1498965_f260.jpg http://people.uwec.edu/piercech/bio/Pictures/plague3.gif

Symptoms (Bubonic Plague) - Gangrene - Chills - High fever - Muscle cramps - Seizures - Swollen lymph glands - Skin discoloration - Bleeding of the ears http://rlv.zcache.com/main_symptoms_of_black_death_bubonic_plague_chart_poster-r7976f470e1824a8eb1fbe096a5b00c6f_azzc8_400.jpg

Why is it less common today? - Increase in overall hygiene - Decrease in infected organisms - Change in climate - (1:56-2:58) http://www.youtube.com/watch?v=pRZYb2Jl22 g