Edward P. Riley, Ph.D. Principal Investigator Administrative Core Edward P. Riley, Ph.D. Principal Investigator

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Developmental Projects Solicited applications, received 30, 1page applications Narrowed it down to 10 for further consideration, reviewed 9 of these Reviewed by outside committee chaired by John Hannigan Funded 2 new developmental projects. C. Tesche R. Miranda Ammon The Effects of Alcohol Exposure and Maternal Nutrition on Infant Nutrition Bahkireva Fatty Acid Ethyl Esters and Proteomics / Genomics Placenta Measures as Biomarkers of Prenatal Alcohol Exposure Barron Pharmacological Interventions to Reduce FASD: A Focus on alpha-7 nAChR Cholinergic Agonists Lapham Computer-Assisted Interviews to Detect Binge Drinking in Pregnancy. Li Morphological Characteristic of Alcohol-Induced Holoprosencephaly Miranda Circulating microRNA Biomarkers of Fetal Alcohol Exposure Pierzykowski Non-coding RNA in pathogenesis of neuro-facial dysmorphology in mouse FASD model Rovet Improving Self-Regulation In Children with Fetal Alcohol Spectrum Disorders: A Neuroplastic Intervention Tesche A Neuroplastic Intervention

Applications for Developmental Projects Ammon The Effects of Alcohol Exposure and Maternal Nutrition on Infant Nutrition Bahkireva Fatty Acid Ethyl Esters and Proteomics / Genomics Placenta Measures as Biomarkers of Prenatal Alcohol Exposure Barron Pharmacological Interventions to Reduce FASD: A Focus on alpha-7 nAChR Cholinergic Agonists Lapham Computer-Assisted Interviews to Detect Binge Drinking in Pregnancy. Li Morphological Characteristic of Alcohol-Induced Holoprosencephaly Miranda Circulating microRNA Biomarkers of Fetal Alcohol Exposure Pierzykowski Non-coding RNA in pathogenesis of neuro-facial dysmorphology in mouse FASD model Rovet Improving Self-Regulation In Children with Fetal Alcohol Spectrum Disorders: A Neuroplastic Intervention Tesche A Neuroplastic Intervention

Google Docs & Charts Sampling from 12/1/2009 Foroud 3D Imaging Sowell Neuroimaging Mattson Neurobehavioral

Central Repository Update Monthly Data Report for the Central Repository of the Collaborative Initiative on Fetal Alcohol Spectrum Disorders December 31, 2009 Rows represent types of data. Columns represent different projects. Each cell represents the number of subjects from a given project for which a given type of data has been submitted to the central repository. Any change from the previous report is represented in each cell by a number proceeded by a ‘+’ or ‘-‘, representing whether the number of subjects/exams increased or decreased. Some projects that have no associated data are not shown in the table above. Central Repository Update

Administrative Core Publications Barrow, M. & Riley, E. (2010). Diagnosis of the Fetal Alcohol Syndrome: Emphasis on Early Detection. In P. Preece and E. Riley (Eds.), Drugs in Pregnancy -The Price for the Child (In press). London, England: MacKeith Press. Guerri, C., Bazinet, A., & Riley, E.P. (2009). Foetal alcohol spectrum disorders and alterations in brain and behaviour. Alcohol and Alcoholism, 44:108-14. Kaminen-Ahola, N., Ahola, A., Maga, A.M., Mallitt, K.A., Fahey, P., Cox, T.C., Whitelaw, E. & Chong, S. (2009). Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model. PLoS Genetics, In press. Kfir, M., Yevtushok, L., Onishchenko, S., Wertelecki, W., Bakhireva, L., Chambers, C.D., Jones. K.L., & Hull, A.D. (2009). Can prenatal ultrasound detect the effects of in utero alcohol exposure? - A pilot study. Ultrasound in Obstetrics and Gynecology, 33:683-9. Riley, E.P. & McGee, C.L. (2010). The Effects of Prenatal Alcohol Exposure on Brain and Behavior. In P. Preece and E. Riley (Eds.), Drugs in Pregnancy -The Price for the Child (In press). London, England: MacKeith Press. Thomas, J.D., Abou, E.J., & Dominguez, H.D. (2009). Prenatal choline supplementation mitigates the adverse effects of prenatal alcohol exposure on development in rats. Neurobehavioral Teratology, 31:303-11.

Administrative Core PI 2009 Talks “Brain and Behavior,” presented at the 1st Congress of Asia-Pacific Society for Alcohol Addiction Research (APSAAR): Together, Asia-Pacific Addiction Researchers, Seoul, Korea, November, 2009 “The Effects of Prenatal Alcohol on Brain and Behavior,” presented at the 56th Annual Meeting of the American Academy of Child & Adolescent Psychiatry, Honolulu, Hawaii, October, 2009. “Brain Pathology in FAS,” presented at the FASD International Symposium, Berlin, Germany, September 2009. “The Effects of Prenatal Alcohol Exposure on Brain and Behavior,” presented at the International Scientific Symposium: The Impact of Alcohol on the Development of the Child – Clinical Picture and Diagnostic Problems in Children with FAS, Poznan, Poland, September, 2009. Commentary on the “ESBRA/ISBRA/APSAAR Joint Symposium: Alcohol Consumption and Related Harm”, provided at the 12th Congress of ESBRA, Helsinki, Finland, June, 2009. “Bi-manual Coordination & Interventions (Behavioural, Nutritional & Pharmacological,” presented at Parents for Children: The Impact on Children of Alcohol & Drugs in Pregnancy: Why do we deny the Risks? conference, London, UK, March 2009. “An International Approach to Research,” CIFASD plenary session presentation at the 3rd International Conference on Fetal Alcohol Spectrum Disorder, The University of British Columbia - Victoria, BC, March, 2009. “An Overview of Current National and International FASD Research,” presented at the National Fetal Alcohol Spectrum Disorders (FASD) Conference: Addressing Social and Behavioral Issues across the Lifespan, The University of Wisconsin - Madison, WI, May, 2009. “Lessons Learned about Social and Behavioral Outcomes,” keynote address at the National Fetal Alcohol Spectrum Disorders (FASD) Conference: Addressing Social and Behavioral Issues across the Lifespan, The University of Wisconsin - Madison, WI, May, 2009. “Review of Evidence: 1973-1998,” presented at the NIAAA Scientific Workshop on Cognitive Deficits, Neurobehavioral Problems and Psychopathology due to Prenatal Alcohol Exposure, Rockville, MD, May, 2009. “The Foetal Brain & Alcohol – Defining Foetal Alcohol Spectrum Disorder,” presented at Parents for Children Consequences for Alcohol & Adolescence: Ways Forward for Foetally Affected Teenagers of their Mothers’ Substance Misuse in Pregnancy conference, Belfast, UK, March, 2009. “FASD, Not Just Another Pretty Face. The Effects of Prenatal Alcohol on Brain and Behavior,” keynote address at the 42nd Annual Gatlinburg Conference on Research and Theory in Intellectual and Developmental Disabilities: Biological and Social Aspects of Environmental Risk in Developmental Disabilities, New Orleans, LA, March, 2009.

Administrative Core PI 2009 Talks