SWAG SSG Skin Meeting Thursday 22nd September 2016 Maxine Taylor Clinical Research Network West of England SWAG SSG Skin Meeting Thursday 22nd September 2016 Maxine Taylor Senior Research Delivery Manager – Cancer, Surgery, Genetics, Haematology. Workforce Development Lead

Clinical Research Network & Cancer Services West ofEngland SWAG - Somerset Wiltsire Avon & Gloucestershire South West Children’s Cancer & Leukaemia Research Network

30 Clinical Specialties Ageing Anaesthetics & pain Cancer Cardiovascular Children Critical Care Dementia & Neurodegenerative Dermatology Diabetes ENT Gastroenterology Genetics Haematology Health Services Hepatology Infectious Diseases Injuries & Emergencies Mental Health Metabolic & Endocrine Musculoskeletal Neurological Opthalmology Oral & Dental Primary Care Public Health Renal Reproductive Health Respiratory Stroke Surgery

NIHR CRN High Level Objectives Increase number of participants into NIHR CRN portfolio studies 650,000 in England 21,905 in West of England Increase the number of studies that deliver to time and target Target 80% Increase number of commercial studies delivered through network 650 new studies this year 75% of all commercial studies Reduce NHS study set up times Reduce time taken to recruit first participant

NIHR CRN Objectives for cancer Recruit 20% of cancer incidence West of England 1,909 Recruit 7.5% of cancer incidence into interventional studies 716 Include challenging studies Cancer surgery – 4 recruits per 100,000 population Radiotherapy – 6 recruits per 100,000 population Rare cancers (<6 per 100,000) – 12 recruits per 100,000 population Children & young people – 3 per 100,000 population Teenagers & young adults – record number of 16-15 year olds participating in research

Including lymphoma

National Clinical Studies Groups PPI Psychosocial & Survivorship Imaging Adv. panel Breast Cancer CSG Brain Tumours CSG Lung Cancer CSG Palliative & Supportive Care Head & Neck CSG Biomarkers Adv. panel Upper GI Cancer CSG Consumer Liaison Group Sarcoma CSG PPI Colorectal Cancer CSG Melanoma CSG Kidney Cancer CSG Primary Care Lymphoma CSG Bladder Cancer CSG Screening, Prevention & Early Diagnosis Haematol. CSG Testis Cancer CSG Prostate Cancer CSG Gynae Cancer CSG Children’s Cancer & Leukaemia Teenage & Young Adult CTRad (Radiotherapy)

2016-17 to date Cancer recruitment per LCRN

2016-17 to date West of England recruitment to Cancer studies per Trust

Studies in setup Currently no studies in setup Open studies per Trust Project Title Chief Investigator Site parent organisation Principal Investigator BRAG rating Project site planned recruitment end date Recruited (total) Project site target participants EORTC 18081 - Adjuvant Pegylated Interferon in Ulcerated Melanoma Gloucestershire Hospitals NHS Foundation Trust Farrugia, Dr David 30/11/2017 8 An Open-Label, Phase 1, Dose Escalation Study of MLN2480 in Patients with Relapsed or Refractory Solid Tumors Followed by a Dose Expansion Phase in Patients With Unresectable Melanoma. Middleton, Prof Mark University Hospitals Bristol NHS Foundation Trust Herbert, Dr Chris 01/08/2016 4 5 Studies in setup Currently no studies in setup BRAG Open studies Black Study not reported recruitment or study has not recruited Red % Recruitment is more than 30 behind % time elapsed, i.e. Difference < -30 Amber % Recruitment is less than 30 behind % elapsed time but more than 0 behind % elapsed time, i.e. -30 < Difference < 0 Green % Recruitment is equal to or greater than % elapsed time, i.e. Difference >= 0 Grey Unable to calculate RAG due to record missing at least one data point

Useful links https://www.crn.nihr.ac.uk/ National and local network information including training programmes templates, tools, contacts, videos etc https://odp.nihr.ac.uk/ http:/ Open data platform. Look at performance across whole CRN including all specialty areas /csg.ncri.org.uk/portfolio/portfolio-maps/ View current national portfolio of open, closed and ‘in set up’ studies https://www.ukctg.nihr.ac.uk/ See where a study in open across the country http://public-odp.nihr.ac.uk/  Search for a study to fit criteria. Good for horizon scanning, eligibility criteria

Contacts Research Delivery Manager – maxine.taylor@nihr.ac.uk Cancer portfolio facilitator – richard.munday@nihr.ac.uk