Creating RDF Representations of Patient Data

Diabetes Patient Data 54-year-old man with diabetes was referred to the Hypertension Clinic in Jichi Medical School Hospital with symptoms of dizziness and orthostatic intolerance. In 2002, he started insulin therapy (Hemoglobin A1c 9 %), and in 2004, he was started on a once daily dose of valsartan 80 mg for hypertension. He sometimes complained of dizziness and fainting while standing. On 13 February 2005, he fell down while riding a bicycle. As the clinic BP was 84/60 mm Hg on 14 March, and the valsartan was stopped. He was referred to otolaryngology and neurology, but no significant abnormalities were detected.

URI subject? or has_symptom? age? “54 years” “Collection of Symptoms” _1 _2 “Dizziness” “Orthostatic Intolerance” maps_to maps_to Snomed URI2 Snomed URI1

Design Choices What are the nodes of this graph? What are the types of the nodes of this graphs (RDF(S)/OWL Classes)? What are the labels of the edges of this graph? How do we decide the classes and instances? How do we deal with Industry Standards such as RIM/CDA/SDTM/DCM + Snomed/NCI Thesaurus etc.? Can node types and edge labels be derived from these standards? Can we have specialized edge (“maps_to”) to link nodes in this graph with Snomed/NCI Thesaurus concepts? How do we choose these to ensure interoperability across multiple standards? How do we represent temporal data and information? How do we capture abstractions such as a clinical event, a patient encounter?

Name Space Issues Proposal: Create Namespaces for each of the standards hl7rim: HL7/RIM dcm: Detailed Clinical Models cda: Clinical Documentation Architecture sdtm: Study Data Tabulation Model snomed: Snomed ncit: NCI Thesaurus

How do we scope this effort? Systolic Blood Pressure Known head injury Suspected head injury Pregnancy Type 2 diabetes FPG HbA1c Women of childbearing potential Type 1 diabetes Ketacidosis History of <Condition/Diagnosis> Severe Diabetic Neuropathy Autonomic Neuropathy Gastroporesis Lower Limb Ulceration Lower Limb Amputation Intentional Weight Loss Period of time for Weight Loss Serum creatinine eGFR Chronic Kidney Disease Stage 3

Proposed Tasks/Groups HL7/RIM: Helen, Vipul, Dan DCM: Tom Oniki, Stan Huff Realist Approach: Kerstin, Bo, Alan SDTM: Rachel, Jennifer POMR: Vipul

Examples of Eligibility Criteria Example Patient Data Various Standards HL7, CDISC, etc. RDF/OWL Graphs