Normalizing Ovulation Rate by Preferential Reduction of Hepato-Visceral Fat in Adolescent Girls With Polycystic Ovary Syndrome Lourdes Ibáñez, M.D.,

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Presentation transcript:

Normalizing Ovulation Rate by Preferential Reduction of Hepato-Visceral Fat in Adolescent Girls With Polycystic Ovary Syndrome Lourdes Ibáñez, M.D., Luis del Río, M.D., Marta Díaz, Ph.D., Giorgia Sebastiani, M.D., Óscar J. Pozo, Ph.D., Abel López-Bermejo, M.D., Francis de Zegher, M.D. Journal of Adolescent Health Volume 61, Issue 4, Pages 446-453 (October 2017) DOI: 10.1016/j.jadohealth.2017.04.010 Copyright © 2017 Society for Adolescent Health and Medicine Terms and Conditions

Figure 1 Longitudinal changes in hepatic fat and free androgenemia Z-scores in adolescent girls with PCOS, who received an OC (red circles; N = 17) or low-dose SPIOMET (blue circles; N = 17) for 12 months and who remained subsequently untreated for 12 months. OC and SPIOMET had opposing effects on hepatic fat; OC lowered free androgenemia faster than SPIOMET but was also followed by a faster rebound. Results are expressed as means and SEM. p values refer to differences between subgroups (0–24 months). Symbols along the x-axis (*p < .05, &p < .01, #p < .001) refer to differential changes between 0 and 6 months and between 12 and 18 months. OC = oral contraceptive; PCOS = polycystic ovary syndrome; SEM = standard error of mean; SPIOMET = spironolactone–pioglitazone–metformin. Journal of Adolescent Health 2017 61, 446-453DOI: (10.1016/j.jadohealth.2017.04.010) Copyright © 2017 Society for Adolescent Health and Medicine Terms and Conditions