Effects of structured patient education in adults with atopic dermatitis: Multicenter randomized controlled trial Annice Heratizadeh, MD, Thomas Werfel,

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Effects of structured patient education in adults with atopic dermatitis: Multicenter randomized controlled trial Annice Heratizadeh, MD, Thomas Werfel, MD, Andreas Wollenberg, MD, Susanne Abraham, MD, Sibylle Plank-Habibi, Christina Schnopp, MD, Michael Sticherling, MD, Christian Apfelbacher, PhD, Tilo Biedermann, MD, Kristine Breuer, MD, Isabel Fell, MD, Regina Fölster-Holst, MD, Guido Heine, MD, Jennifer Grimm, Lars Hennighausen, PhD, Claudia Kugler, Imke Reese, PhD, Johannes Ring, MD, Knut Schäkel, MD, Jochen Schmitt, MD, MPH, Kurt Seikowski, PhD, Esther von Stebut, MD, Nicola Wagner, MD, Anja Waßmann-Otto, PhD, Ute Wienke-Graul, MD, Elke Weisshaar, MD, Margitta Worm, MD, Uwe Gieler, MD, Joerg Kupfer, PhD Katrin Brauner, Sabine Dölle, PhD, Laura Ehmann, MD, Ute Hagmaier, Susanne Eberlein, Julia Kroth, MD, Katja Lämmerhirt, Rosemarie Landleiter, Ute Lorenz, Anja Lüdemann, Uwe Matterne, PhD, Heidrun Mitzel-Rink, MD, Margarete Niebuhr, MD, Tessa Rehberg, Sandra Vogel, Katja Wichmann, MD Annice Heratizadeh, MD, Thomas Werfel, MD, Andreas Wollenberg, MD, Susanne Abraham, MD, Sibylle Plank-Habibi, Christina Schnopp, MD, Michael Sticherling, MD, Christian Apfelbacher, PhD, Tilo Biedermann, MD, Kristine Breuer, MD, Isabel Fell, MD, Regina Fölster-Holst, MD, Guido Heine, MD, Jennifer Grimm, Lars Hennighausen, PhD, Claudia Kugler, Imke Reese, PhD, Johannes Ring, MD, Knut Schäkel, MD, Jochen Schmitt, MD, MPH, Kurt Seikowski, PhD, Esther von Stebut, MD, Nicola Wagner, MD, Anja Waßmann-Otto, PhD, Ute Wienke-Graul, MD, Elke Weisshaar, MD, Margitta Worm, MD, Uwe Gieler, MD, Joerg Kupfer, PhD Katrin Brauner, Sabine Dölle, PhD, Laura Ehmann, MD, Ute Hagmaier, Susanne Eberlein, Julia Kroth, MD, Katja Lämmerhirt, Rosemarie Landleiter, Ute Lorenz, Anja Lüdemann, Uwe Matterne, PhD, Heidrun Mitzel-Rink, MD, Margarete Niebuhr, MD, Tessa Rehberg, Sandra Vogel, Katja Wichmann, MD Journal of Allergy and Clinical Immunology Volume 140, Issue 3, Pages 845-853.e3 (September 2017) DOI: 10.1016/j.jaci.2017.01.029 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Flow of patients through the trial (CONSORT diagram). Journal of Allergy and Clinical Immunology 2017 140, 845-853.e3DOI: (10.1016/j.jaci.2017.01.029) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A, Decrease of catastrophization with respect to itch assessed by using the JKF questionnaire with estimated marginal means (95% CIs) of differences in the training and waiting control groups (baseline versus 1-year follow-up). ***P < .001. B, Reduction in social anxiety assessed by using the MHF questionnaire with estimated marginal means (95% CIs) of differences in the training and waiting control groups (baseline vs 1 year of follow-up). ns, Not significant. Journal of Allergy and Clinical Immunology 2017 140, 845-853.e3DOI: (10.1016/j.jaci.2017.01.029) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Reduction in burden by symptoms caused by AD assessed by using the Skindex-29 questionnaire with estimated marginal means (95% CIs) of differences in the training and waiting control groups (baseline vs 1 year of follow-up; missing data = 3). ***P < .001. Journal of Allergy and Clinical Immunology 2017 140, 845-853.e3DOI: (10.1016/j.jaci.2017.01.029) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Reduction in signs and symptoms of AD. Results from assessment by using the SCORAD index (A; missing data = 4), corresponding objective SCORAD index (B; missing data = 2), and PO-SCORAD index (C; missing data = 4) with estimated marginal means (95% CIs) of differences in the training and waiting control groups (baseline vs 1 year of follow-up). *P < .05 and ***P < .001. Journal of Allergy and Clinical Immunology 2017 140, 845-853.e3DOI: (10.1016/j.jaci.2017.01.029) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Change in SCORAD index (A) and objective SCORAD (B) scores from baseline versus 1 year of follow-up. Cumulative proportion of patients achieving at least 30% (SCORAD 30), 50% (SCORAD 50), and 75% (SCORAD 75) improvement in the training and waiting control groups is shown. *P < .05, **P < .01, and ***P < .001. Journal of Allergy and Clinical Immunology 2017 140, 845-853.e3DOI: (10.1016/j.jaci.2017.01.029) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions