TCRN F2F Meeting 2016

Roswell Park Cancer Institute Located in Buffalo, New York 27 acre main campus and five affiliated sites Independent, free standing cancer institute since 1898 NCI designated comprehensive cancer center since 1974 133 hospital beds 3,282 employees 309 faculty members and over 100 senior scientists 20 scientific shared resources

Roswell Park Cancer Institute 5,284 hospital admissions, 224,000 outpatient visits, 31,000 patients under active care/year Cancer Registry Cases In 2015: 4,067 ( analytic class 00-22) 480 (non-analytic class 32: 1st course treatment elsewhere, subsequent treatment at RPCI) 2,160 (non-analytic class 30-43, including consults, e.g., path) Service/Referral Areas Primary catchment area: 8 county regions of Western New York, 1.5 M (86%) of RPCI patients 48 states 13 foreign countries

Current RPCI TIES Statistics Loaded path reports Time span: 1995 to 09/2016 Patients: 90,203 Reports: 195,174 38,372 reports, 2014-9/2016, recently loaded, being QCed Live HL7 feed every six months beyond 9/2016 Registered users: 26

IT Tasks Completed since last F2F Loaded surgical pathology reports from 1/1/2014 to 9/15/2016 Upgraded to TIES v 5.6.2 Performed validation of 2002 to 2016 cases uploaded into TIES against Tamtron Missing reports were re-exported to be included in TIES IT support, development, and maintenance 

Next IT Tasks Run RPCI PHI checker scripts on newly loaded reports (1/1/2014 and 9/15/2016) QC 2014 - 9/2016 pathology reports Review and revise errors in reports, e.g., MRNs format and missing names Website update Support evaluation and validation of new De-ID tool Implement LDAP with TIES Support upcoming development for CR data import into TIES

Quality Control User Audit – 6 months intervals Query Audit – annually July 2016 audit – no issues to report Query Audit – annually Dec 2015 audit – no issues to report

Progress TIES has been live as 09/09/2015 26 active user accounts (14 in 2015) 4 fellows currently use TIES for research projects TIES/TCRN Dissemination Presentation and Demo Disease Site Research Groups (10) CCSG Scientific Programs (5) Fellows Website, fliers, Mission Magazine article Pilot Projects

Pilot Projects Skin ulceration in breast cancer staging (Dr. Thaer Khoury) RPCI & UPitt Manuscript accepted for publication Oct 2016, Breast Journal: “The Role of Skin Ulceration in Breast Carcinoma Staging and Outcome” TBJ-00372-2016.R1 Intramammary LN, (Dr. Thaer Khoury) Research in progress RPCI, UPitt, UPen, AU

Supported External Projects Demographic characterization of tenosynovial giant cell tumor, AU Gene expression in endometriosis and endometriosis associated ovarian cancer, UPitt Margin evaluation in early carcinomas of the oral tongue, UPitt Skin cancer in post transplant patients, UPitt

RPCI Investigators/TIES User Questions/Interest What other clinical data is accessible? Would you have molecular results? Could you also search radiology reports? (Clinical staging) Can you search other centers data without IRB approval? Could RPCI investigators search radiology reports loaded in other TIES nodes? Awareness and level of interest is significantly growing

RPCI-TIES/TCRN Team and Roles Dr. Carmelo Gaudioso, RPCI CoI., Executive TCRN Committee member Monica Lopez Murphy, TIES Regulatory Administrator and TCRN P & P subcommittee member Kelly Jans, TIES Regulatory Administrator, user educator Mayur Sakthivel, TIES IT Administrator, responsible for RPCI TIES IT development

Q&A Thanks! Questions-Comments?