Bioinformatics Overview Bioinformatics is the application of information technology to the management of biological data. Bioinformaticians understand biological problems and computational solutions to produce useful tools.

Bioinformatics Outline Molecular Biology Data Searches Substitution Patterns Phylogenetics Genomics Protein and DNA Structure Prediction Proteomics

Bioinformatics Outline Perl Bioinformatics tools

Molecular Biology Genetic material Gene structure Protein structure Molecular biology tools Genomic information

Data Searches Dot plots Alignments Scoring matrices Dynamic programming Global and local alignments Multiple sequence alignments Database searches

Substitution Patterns Patterns of substitutions with Genes Substitution numbers Variations in Evolutionary rates Molecular clocks

Phylogenetics Molecular phylogenetics Phylogenetic trees Distance matrix methods Maximum likelihood approaches Multiple sequence alignments

Phylogenetics Parsimony Inferred ancestral sequences Faster searches Consensus trees Tree confidence Molecular phylogenies

Genomics Prokaryotic genomes Prokaryotic gene structure GC content Prokaryotic gene density

Genomics Eukaryotic gene structure Open reading frames GC content Gene expression Transposition Eukaryotic gene density

Protein and DNA Structure Prediction Amino acids Polypeptide composition Secondary structure Tertiary and quaternary structure Modeling protein folding Structure prediction

Proteomics Protein classification Experimental techniques Inhibitors and drug design Empirical methods NMR structure Post-translational modification prediction

Perl for Bioinformatics Getting started with Perl Sequences and strings Mutation and randomization Genetic code

Bioinformatics Tools equence analysis, pairwise alignment, and database searching Multiple sequence alignments Visualizing pattern structures Prediction protein structure and function from sequence Genomics and proteomics