J. Larkin, D. Soden, C. Collins, M. Tangney, J. M. Preston, L. J

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Combined electric field and ultrasound therapy as a novel anti-tumour treatment J. Larkin, D. Soden, C. Collins, M. Tangney, J.M. Preston, L.J. Russell, A.P. McHale, C. Dunne, G.C. O’Sullivan European Journal of Cancer Volume 41, Issue 9, Pages 1339-1348 (June 2005) DOI: 10.1016/j.ejca.2005.01.025 Copyright © 2005 Elsevier Ltd Terms and Conditions

Fig. 1 Tumour growth curves for four groups of athymic nude mice (n=6) bearing tumours of the human oesophageal adenocarcinoma line OE19. The groups were treated with either CEFUS, ultrasound alone, electric field alone or were left as untreated controls. European Journal of Cancer 2005 41, 1339-1348DOI: (10.1016/j.ejca.2005.01.025) Copyright © 2005 Elsevier Ltd Terms and Conditions

Fig. 2 Tumour growth curves for three groups of athymic nude mice (n=11) bearing tumours of the human oesophageal adenocarcinoma line OE19. Two of the groups received CEFUS treatment. The electric field was delivered to one group using intratumoural needle electrodes and to the other group using subcutaneous parallel needle electrodes. European Journal of Cancer 2005 41, 1339-1348DOI: (10.1016/j.ejca.2005.01.025) Copyright © 2005 Elsevier Ltd Terms and Conditions

Fig. 3 Comparison of exponential/square wave pulses using parallel/intratumoral needle electrodes to deliver the electric field component of CEFUS. The ultrasound parameters used were 3.5W/cm2 intensity, 35% duty cycle at a frequency of 1MHz for 2min. Control plot is a representative curve from samples that were: untreated, ultrasound alone, square wave pulse intratumoral needle electrodes, exponential pulse with parallel needle electrodes, square wave pulse with parallel needle electrodes and exponential pulse with intratumoral needle electrodes. There were no significant differences between the individual control treatment conditions. European Journal of Cancer 2005 41, 1339-1348DOI: (10.1016/j.ejca.2005.01.025) Copyright © 2005 Elsevier Ltd Terms and Conditions

Fig. 4 Focal areas of apoptosis induced in C26 tumour tissue after (a) 24h after CEFUS treatment. (b) No evidence of apoptosis is seen in the untreated control (c) or in tumours treated by ultrasound (d) or by electric field alone after 24h. European Journal of Cancer 2005 41, 1339-1348DOI: (10.1016/j.ejca.2005.01.025) Copyright © 2005 Elsevier Ltd Terms and Conditions

Fig. 5 Comparison of mouse thigh tissue following application of CEFUS. (a) Untreated control and (b) CEFUS treated sample. No evidence of apoptosis was detected in the muscle tissue at any time point up to 96h after exposure to the treatment protocol. European Journal of Cancer 2005 41, 1339-1348DOI: (10.1016/j.ejca.2005.01.025) Copyright © 2005 Elsevier Ltd Terms and Conditions

Fig. 6 Haematoxylin and eosin stained mouse thigh muscle: (a) control tissue or (b) tissue exposed 48h previously to electric pulses or (c) ultrasound (d) or the CEFUS protocol. European Journal of Cancer 2005 41, 1339-1348DOI: (10.1016/j.ejca.2005.01.025) Copyright © 2005 Elsevier Ltd Terms and Conditions