Volume 376, Issue 9736, Pages 180-188 (July 2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study  Thomas J Wang, MD, Feng Zhang, PhD, J Brent Richards, MD, Bryan Kestenbaum, MD, Joyce B van Meurs, PhD, Diane Berry, MSc, Douglas P Kiel, MD, Elizabeth A Streeten, MD, Prof Claes Ohlsson, PhD, Daniel L Koller, PhD, Prof Leena Peltonen, PhD, Jason D Cooper, PhD, Paul F O'Reilly, PhD, Denise K Houston, PhD, Nicole L Glazer, PhD, Liesbeth Vandenput, PhD, Prof Munro Peacock, DSc(Med), Julia Shi, MSc, Fernando Rivadeneira, PhD, Prof Mark I McCarthy, FMedSci, Pouta Anneli, PhD, Ian H de Boer, MD, Massimo Mangino, PhD, Bernet Kato, PhD, Deborah J Smyth, BSc, Prof Sarah L Booth, PhD, Paul F Jacques, ScD, Prof Greg L Burke, MD, Prof Mark Goodarzi, PhD, Ching-Lung Cheung, PhD, Myles Wolf, MD, Kenneth Rice, PhD, Prof David Goltzman, MD, Nick Hidiroglou, PhD, Martin Ladouceur, PhD, Prof Nicholas J Wareham, PhD, Lynne J Hocking, PhD, Deborah Hart, PhD, Prof Nigel K Arden, MD, Prof Cyrus Cooper, FMedSci, Suneil Malik, PhD, Prof William D Fraser, MD, Prof Anna-Liisa Hartikainen, PhD, Guangju Zhai, PhD, Helen M Macdonald, PhD, Nita G Forouhi, FFPH, Ruth JF Loos, PhD, Prof David M Reid, MD, Alan Hakim, MA, Elaine Dennison, PhD, Yongmei Liu, PhD, Prof Chris Power, PhD, Helen E Stevens, HNC, Laitinen Jaana, PhD, Prof Ramachandran S Vasan, DM, Nicole Soranzo, PhD, Jörg Bojunga, MD, Prof Bruce M Psaty, PhD, Mattias Lorentzon, PhD, Prof Tatiana Foroud, PhD, Tamara B Harris, MD, Prof Albert Hofman, MD, Prof John-Olov Jansson, PhD, Jane A Cauley, PhD, Prof Andre G Uitterlinden, PhD, Quince Gibson, MBA, Prof Marjo-Riitta Järvelin, PhD, David Karasik, PhD, Prof David S Siscovick, MPH, Prof Michael J Econs, MD, Prof Stephen B Kritchevsky, PhD, Jose C Florez, PhD, Prof John A Todd, PhD, Prof Josee Dupuis, PhD, Elina Hyppönen, PhD, Prof Timothy D Spector, MD  The Lancet  Volume 376, Issue 9736, Pages 180-188 (July 2010) DOI: 10.1016/S0140-6736(10)60588-0 Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 1 Regional linkage disequilibrium plots for single nucleotide polymorphisms at GC (A), DHCR7/NADSYN1 (B), CYP2R1 (C), and CYP24A1 (D) The Lancet 2010 376, 180-188DOI: (10.1016/S0140-6736(10)60588-0) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 2 Risk of vitamin D insufficiency*, by quartile of genotype score *25-hydroxyvitamin D concentration lower than 75 nmol/L. Error bars show 95% CIs. The Lancet 2010 376, 180-188DOI: (10.1016/S0140-6736(10)60588-0) Copyright © 2010 Elsevier Ltd Terms and Conditions