Transformation is a multistep process

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Presentation transcript:

Transformation is a multistep process

Colorectal Cancer 11% of cancer-related deaths Tumor progression may take 10-35 years Adenomatous polyp develops into carcinoma

Chromosome changes in colorectal cancer Cancer karyotype Stable karyotype

reading URLs: http://www.infobiogen.fr/services/chromcancer/Kprones/RbKprID10031.html http://cgap.nci.nih.gov/ http://www.intouchlive.com/home/frames.htm?http://www.intouchlive.com/cancergenetics/&3 http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/p53.htm Books: Concepts of Genetics, Klug and Cummings, chapter 23 Molecular Biology of the Cell