Volume 370, Issue 9600, Pages (November 2007)

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Journal Club 亀田メディカルセンター糖尿病内分泌内科 Diabetes and Endocrine Department, Kameda Medical Center 松田昌文 Matsuda, Masafumi 2007 年 12 月６日 8:20-8:50 B 棟８階カンファレンス室.

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Volume 370, Issue 9600, Pages 1687-1697 (November 2007) Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial Prof AC Keech, FRACP, Prof P Mitchell, FRANZCO, PA Summanen, FEBO, J O'Day, FRANZCO, Prof TME Davis, MRCP, MS Moffitt, DipTc, Prof M-R Taskinen, MD, Prof RJ Simes, FRACP, D Tse, PhD, E Williamson, PhD, A Merrifield, PhD, Prof LT Laatikainen, FEBO, MC d'Emden, FRACP, DC Crimet, MD, RL O'Connell, MMedStat, Prof PG Colman, FRACP The Lancet Volume 370, Issue 9600, Pages 1687-1697 (November 2007) DOI: 10.1016/S0140-6736(07)61607-9 Copyright © 2007 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile (A) FIELD study. (B) Ophthalmology substudy. The Lancet 2007 370, 1687-1697DOI: (10.1016/S0140-6736(07)61607-9) Copyright © 2007 Elsevier Ltd Terms and Conditions

Figure 2 Cumulative risk curves of time to event of any first laser treatment, by treatment group Macular oedema indicates laser treatment where the macula was involved; proliferative retinopathy shows cases without macular involvement; all retinopathy includes all first instances of laser treatment for any diabetic retinopathy. The Lancet 2007 370, 1687-1697DOI: (10.1016/S0140-6736(07)61607-9) Copyright © 2007 Elsevier Ltd Terms and Conditions

Figure 3 Effect of fenofibrate on first and all laser treatment events Counts for each underlying pathology are shown; for first events, a patient was counted only once under each type of pathology listed; for all events, all courses of laser treatment for each type of pathology are counted (Poisson method). *Without macular involvement. The Lancet 2007 370, 1687-1697DOI: (10.1016/S0140-6736(07)61607-9) Copyright © 2007 Elsevier Ltd Terms and Conditions

Figure 4 Ophthalmology substudy (A) Distribution of patients and proportion of laser treatment events by ETDRS grading of retinopathy at baseline; (B) number of laser treatment events in each treatment group by ETDRS grading of retinopathy at baseline. The Lancet 2007 370, 1687-1697DOI: (10.1016/S0140-6736(07)61607-9) Copyright © 2007 Elsevier Ltd Terms and Conditions