Implantable Cardioverter-Defibrillators for Primary Prevention of Sudden Cardiac Death in CKD: A Meta-analysis of Patient-Level Data From 3 Randomized.

Slides:

Advertisements

Similar presentations

ICD FOR PRIMARY PREVENTION EVIDENCE REVIEW

Advertisements

Sudden Cardiac Death in Heart Failure Trial Presented at American College of Cardiology Scientific Sessions 2004 Presented by Dr. Gust H. Bardy SCD-HeFTSCD-HeFT.

Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: ACC/AHA/ESC 2006 Guidelines for Management of Patients.

Date of download: 6/25/2016 Copyright © The American College of Cardiology. All rights reserved. From: Medical Therapy With Versus Without Revascularization.

Date of download: 6/26/2016 Copyright © The American College of Cardiology. All rights reserved. From: Clinical Effectiveness of CRT and ICD Therapy in.

Date of download: 6/28/2016 Copyright © The American College of Cardiology. All rights reserved. From: Limitations of Ejection Fraction for Prediction.

Date of download: 7/1/2016 Copyright © The American College of Cardiology. All rights reserved. From: The Scope of Coronary Heart Disease in Patients With.

Myocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary.

John W. Pickering, PhD, Matthew T. James, MD, PhD, FRCPC, Suetonia C

Michael J. Koren, MD, Michael H. Davidson, MD, Daniel J

Fredrik Karlsson, MD, Angelo Modica, MD, Thomas Mooe, MD, PhD

Clinical presentation of myocardial infarction contributes to lower use of coronary angiography in patients with chronic kidney disease D.M. Charytan,

Copyright © 2006 American Medical Association. All rights reserved.

Association Between Cardiac Biomarkers and the Development of ESRD in Patients With Type 2 Diabetes Mellitus, Anemia, and CKD Akshay S. Desai, MD, MPH,

A contemporary analysis of pulmonary hypertension in patients undergoing mitral valve surgery: Is this a risk factor? Daniel H. Enter, MD, Anthony Zaki,

The most common cause of death in North America is cardiac death and the most common cause of cardiac death is sudden death from ventricular arrhythmias.

Clinical presentation of myocardial infarction contributes to lower use of coronary angiography in patients with chronic kidney disease D.M. Charytan,

Development of Clinical Practice Guidelines in the Care of People With Kidney Disease: Core Curriculum 2016 Angela C. Webster, PhD, Evi V. Nagler, MD,

Ragavendra R. Baliga, MD, MBA Heart Failure Clinics

Early Invasive Versus Initial Conservative Strategies for Women with Non–ST-Elevation Acute Coronary Syndromes: A Nationwide Analysis Islam Y. Elgendy,

Metabolic Complications in Elderly Adults With CKD

Do higher-risk patients benefit from off-pump coronary artery bypass grafting? Evidence from an ecologic analysis of randomized trials Oliver Kuss, PhD,

Renin-Angiotensin System Inhibitors and Kidney and Cardiovascular Outcomes in Patients With CKD: A Bayesian Network Meta-analysis of Randomized Clinical.

Jessica W. Weiss, MD, Eric S. Johnson, PhD, Amanda Petrik, MS, David H

Increased late mortality after coronary artery bypass surgery complicated by isolated new-onset atrial fibrillation: A comprehensive propensity-matched.

Francesca Mallamaci, MD, Giovanni Tripepi, PhD

A Decade After the KDOQI CKD Guidelines

Cardiovascular Disease and CKD: Core Curriculum 2010

Misconceptions and Facts About Hypertrophic Cardiomyopathy

David F. Katz et al. JACEP 2016;j.jacep

Impact of Electronic Acute Kidney Injury (AKI) Alerts With Automated Nephrologist Consultation on Detection and Severity of AKI: A Quality Improvement.

Zachary R. McCaw, AM, Ariela R

A New Clinical Prediction Tool for 5-Year Kidney Transplant Outcome

Chronic Kidney Disease, Basal Insulin Glargine, and Health Outcomes in People with Dysglycemia: The ORIGIN Study Vasilios Papademetriou, MD, DSc, Eric.

Long-Term Survival of Patients With Ischemic Cardiomyopathy Treated by Coronary Artery Bypass Grafting Versus Medical Therapy Eric J. Velazquez, MD,

Juan A. Crestanello, MD, Richard C. Daly, MD

Why surgery won the SYNTAX trial and why it matters

GFR Decline as an End Point for Clinical Trials in CKD: A Scientific Workshop Sponsored by the National Kidney Foundation and the US Food and Drug Administration

Utility and Validity of Estimated GFR–Based Surrogate Time-to-Event End Points in CKD: A Simulation Study Tom Greene, PhD, Chia-Chen Teng, MS, Lesley.

Association of Waist Circumference and Body Mass Index With All-Cause Mortality in CKD: The REGARDS (Reasons for Geographic and Racial Differences in.

Ioannis Koulouridis, MD, MS, Lori Lyn Price, MAS, Nicolaos E

Baseline Kidney Function as Predictor of Mortality and Kidney Disease Progression in HIV-Positive Patients Fowzia Ibrahim, MSc, Lisa Hamzah, MRCP, Rachael.

Mahesh Anantha Narayanan et al. JACEP 2017;3:

Renin-Angiotensin System Inhibitors and Kidney and Cardiovascular Outcomes in Patients With CKD: A Bayesian Network Meta-analysis of Randomized Clinical.

Yousef Rezaei, MD American Journal of Kidney Diseases

Volume 14, Issue 12, Pages (December 2017)

Outcomes After Ventricular Fibrillation Out-of-Hospital Cardiac Arrest: Expanding the Chain of Survival T. Jared Bunch, MD, Stephen C. Hammill, MD, Roger.

Management of Heart Failure in Advancing CKD: Core Curriculum 2018

Effect of Intensive Insulin Therapy and Pentastarch Resuscitation on Acute Kidney Injury in Severe Sepsis George Thomas, MD, MPH, Ethan M. Balk, MD,

On Statin Treatment to Prevent Sepsis in Dialysis Patients

GFR Decline and Subsequent Risk of Established Kidney Outcomes: A Meta-analysis of 37 Randomized Controlled Trials Hiddo J. Lambers Heerspink, PhD, Hocine.

CKD and the Risk of Acute, Community-Acquired Infections Among Older People With Diabetes Mellitus: A Retrospective Cohort Study Using Electronic Health.

A decade after the Surgical Treatment for Ischemic Heart Failure (STICH) trial: Weaving firm clinical recommendations from lessons learned Robert E.

Comparison of prescription rates and clinical outcomes in acute coronary syndrome patients who underwent percutaneous coronary intervention using different.

Volume 7, Issue 7, Pages (July 2010)

David F. Katz et al. JACEP 2017;3:20-28

A Decade After the KDOQI CKD Guidelines: A Perspective From Mexico

Volume 76, Issue 6, Pages (September 2009)

Beef Tea, Vitality, Creatinine, and the Estimated GFR

Myocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary.

Aortic Valve Replacement for Patients With Severe Aortic Stenosis: Risk Factors and Their Impact on 30-Month Mortality Edward L. Hannan, PhD, Zaza Samadashvili,

Mahesh Anantha Narayanan et al. JACEP 2017;j.jacep

Shannon M. Dunlay, MD, MS, Quinn R. Pack, MD, Randal J

Effect of a Carbonaceous Oral Adsorbent on the Progression of CKD: A Multicenter, Randomized, Controlled Trial Tadao Akizawa, MD, PhD, Yasushi Asano,

Volume 8, Issue 3, Pages (March 2011)

Peter A. McCullough, MD, MPH, Christopher T. Chan, MD, Eric D

KDOQI Clinical Practice Guideline and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease: 2007 Update of Hemoglobin Target American.

Michael J. Germain, MD, Sara N. Davison, MD, Alvin H. Moss, MD

Guidance for the use of bilateral internal thoracic arteries according to survival benefit across age groups Umberto Benedetto, MD, PhD, Mohamed Amrani,

Volume 16, Issue 6, Pages (June 2019)

Presentation transcript:

Implantable Cardioverter-Defibrillators for Primary Prevention of Sudden Cardiac Death in CKD: A Meta-analysis of Patient-Level Data From 3 Randomized Trials Patrick H. Pun, MD, MHS, Sana M. Al-Khatib, MD, MHS, Joo Yoon Han, BS, Rex Edwards, BA, Gust H. Bardy, MD, J. Thomas Bigger, MD, Alfred E. Buxton, MD, Arthur J. Moss, MD, Kerry L. Lee, PhD, Richard Steinman, AB, Paul Dorian, MD, Al Hallstrom, PhD, Riccardo Cappato, MD, Alan H. Kadish, MD, Peter J. Kudenchuk, MD, Daniel B. Mark, MD, MPH, Paul L. Hess, MD, Lurdes Y.T. Inoue, PhD, Gillian D. Sanders, PhD American Journal of Kidney Diseases Volume 64, Issue 1, Pages 32-39 (July 2014) DOI: 10.1053/j.ajkd.2013.12.009 Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Study selection and patient inclusion within selected studies. Abbreviations: AVID, Antiarrhythmics Versus Implantable Defibrillators; CABG-PATCH, Coronary Artery Bypass Graft Patch; CASH, Cardiac Arrest Study Hamburg; CHF, congestive heart failure; DEFINITE, Defibrillators in Non-ischemic Cardiomyopathy Treatment Evaluation; DINAMIT, Defibrillator in Acute Myocardial Infarction Trial; ICD, implantable cardioverter-defibrillator; LVEF, left ventricular ejection fraction; MADIT, Multicenter Automatic Defibrillator Implantation Trial; MUSTT, Multicenter Unsustained Tachycardia Trial; NYHA, New York Heart Association; RCT, randomized controlled trial; SCD-HeFT, Sudden Cardiac Death in Heart Failure Trial. American Journal of Kidney Diseases 2014 64, 32-39DOI: (10.1053/j.ajkd.2013.12.009) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Kaplan-Meier survival curves in implantable cardioverter-defibrillator (ICD) recipients versus nonrecipients according to estimated glomerular filtration rate (eGFR). Unadjusted hazard ratios for the mortality benefit of ICDs are 0.92 and 0.53 (95% confidence intervals, 0.74-1.14 and 0.42-0.67) for eGFRs<60 and ≥60mL/min/1.73m2. American Journal of Kidney Diseases 2014 64, 32-39DOI: (10.1053/j.ajkd.2013.12.009) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Proportion (%) of study participants with adverse outcomes by estimated glomerular filtration rate (eGFR) group. Abbreviations: CKD, chronic kidney disease; Comp, complications; Cont, control arm; eGFR, estimated glomerular filtration rate; ICD, implantable cardioverter-defibrillator; Rehosp, rehospitalizations. American Journal of Kidney Diseases 2014 64, 32-39DOI: (10.1053/j.ajkd.2013.12.009) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 4 Bayesian Weibull covariate-adjusted hazard ratio for mortality benefit of an implantable cardioverter-defibrillator (ICD) as a function of baseline estimated glomerular filtration rate (eGFR). Shaded areas reflect 95% point-wise posterior credible intervals. American Journal of Kidney Diseases 2014 64, 32-39DOI: (10.1053/j.ajkd.2013.12.009) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 5 Forest plots of covariate-adjusted hazard rations (HRs) and 95% posterior credible intervals (PCIs) for (A) all-cause mortality and (B) rehospitalizations by clinical trial and estimated glomerular filtration rate (eGFR) group, with x-axis displayed in the log-scale. Abbreviations: ICD, implantable cardioverter-defibrillator; MADIT, Multicenter Automatic Defibrillator Implantation Trial; OR, odds ratio; SCD-HeFT, Sudden Cardiac Death in Heart Failure Trial. American Journal of Kidney Diseases 2014 64, 32-39DOI: (10.1053/j.ajkd.2013.12.009) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions