Clinical, pathologic and epidemiologic features of infection with Scedosporium prolificans: four cases and review Iain B. Gosbell, Michelle L. Morris, John H. Gallo, Kerry A. Weeks, Stephen A. Neville, Anthony H. Rogers, Ross H. Andrews, David H. Ellis Clinical Microbiology and Infection Volume 5, Issue 11, Pages 672-686 (November 1999) DOI: 10.1111/j.1469-0691.1999.tb00513.x Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions
Figure 1 (a) VITAL blood culture bottle collected from case 2 on 6 June 1996 and examined on 13 June 1996, showing fungal mycelia; the machine, however, had not signaled. (b) Gram stain of a blood culture broth from case 2, showing fungal elements suggestive of Scedosporium prolificans. This species was subsequently isolated from blood and cerebrospinal fluid samples. Clinical Microbiology and Infection 1999 5, 672-686DOI: (10.1111/j.1469-0691.1999.tb00513.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions
Figure 2 Various autopsy photographs of case 2. (a) Right eye with proptosis and hemorrhagic chemosis. (b) Multiple abscesses in myocardium. (c) Mycotic aneurysm of basilar artery. (d) Methenamine silver stain of basilar artery aneurysm, showing fungal hyphae and conidia. Clinical Microbiology and Infection 1999 5, 672-686DOI: (10.1111/j.1469-0691.1999.tb00513.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions
Figure 2 Various autopsy photographs of case 2. (a) Right eye with proptosis and hemorrhagic chemosis. (b) Multiple abscesses in myocardium. (c) Mycotic aneurysm of basilar artery. (d) Methenamine silver stain of basilar artery aneurysm, showing fungal hyphae and conidia. Clinical Microbiology and Infection 1999 5, 672-686DOI: (10.1111/j.1469-0691.1999.tb00513.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions
Figure 3 (a) Blankophor's stain of aspirate of skin lesions of case 3, showing fungal hyphae. (b) Facial appearance of case 3 at autopsy, showing multiple purple macules with central umbilication. Clinical Microbiology and Infection 1999 5, 672-686DOI: (10.1111/j.1469-0691.1999.tb00513.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions
Figure 4 Dendrogram depicting the genetic relationships between eight Scedosporium prolificans isolates as determined by allozyme electrophoresis at 14 enzyme loci and processed by an unweighted pair-group method of analysis. Clinical Microbiology and Infection 1999 5, 672-686DOI: (10.1111/j.1469-0691.1999.tb00513.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions