KEY CONCEPT Genes can be mapped to specific locations on chromosomes.

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KEY CONCEPT Genes can be mapped to specific locations on chromosomes.

Gene linkage was explained through fruit flies. Morgan found that linked traits are on the same chromosome. Chromosomes, not genes, assort independently during meiosis. (Line up in random order during metaphase 1) Where one chromosome lines up does not affect how any of the others line up. Wild type Mutant

Linkage maps estimate distances between genes. Linkage maps show the relative locations of genes. The closer together two genes are, the more likely they will be inherited together.

Linked genes are often inherited together BUT…. Linked genes are not inherited together every time. Chromosomes exchange homologous genes during meiosis.

Linkage maps estimate distances between genes. The closer together two genes are, the more likely they will be inherited together. Cross-over frequencies are related to distances between genes.

Cross-over frequencies can be converted into map units. gene A and gene B cross over 6.0 percent of the time gene B and gene C cross over 12.5 percent of the time gene A and gene C cross over 18.5 percent of the time So which two genes are the farthest apart on the chromosome?

gene A and gene B cross over 6.0 percent of the time gene B and gene C cross over 12.5 percent of the time gene A and gene C cross over 18.5 percent of the time So which two genes are the farthest apart on the chromosome?