Glucocorticoid receptor gene modulates severity of depression in women with crack cocaine addiction Diego L. Rovaris, Angelita P. Aroche, Bruna S. da Silva, Djenifer B. Kappel, Júlio C. Pezzi, Mateus L. Levandowski, Adriana R.B. Hess, Jaqueline B. Schuch, Rosa M.M. de Almeida, Rodrigo Grassi-Oliveira, Claiton H.D. Bau European Neuropsychopharmacology Volume 26, Issue 9, Pages 1438-1447 (September 2016) DOI: 10.1016/j.euroneuro.2016.06.010 Copyright © 2016 Elsevier B.V. and ECNP Terms and Conditions
Figure 1 Effect of NR3C1-rs41423247 SNP on depressive symptoms during detoxification treatment of crack cocaine addicts. A) There was an effect of NR3C1-rs41423247 SNP on BDI estimated overall means (n=390). B) There was no NR3C1-rs41423247-time interaction. Generalized estimating equation model (three assessments: T1 n=142, T2 n=135 and T3 n=113) adjusted for ethnicity. Data are expressed as mean and standard error of the mean. BDI-II=Beck Depression Inventory. *P=0.0037 (Table 1). European Neuropsychopharmacology 2016 26, 1438-1447DOI: (10.1016/j.euroneuro.2016.06.010) Copyright © 2016 Elsevier B.V. and ECNP Terms and Conditions
Figure 2 Mean depressive symptoms of crack cocaine addicts at early and late abstinence according to NR3C1-rs41423247 genotypes. BDI-II scores were classified according to guidelines that suggest interpreting them as follow: minimal range 0–13, mild depression 14–19, moderate depression 20–28, and severe depression 29–63 (Gorenstein and Andrade, 1996). European Neuropsychopharmacology 2016 26, 1438-1447DOI: (10.1016/j.euroneuro.2016.06.010) Copyright © 2016 Elsevier B.V. and ECNP Terms and Conditions