Our expertise, your advantage GE Healthcare Fast Trak Training & Education Our expertise, your advantage 2017 Advanced Bioreactor Cultivation Technology Course (CELL 2), TAIWAN After the course you will be able to :  Control and evaluate batch and fed-batch and cultures  Perform basic characterization of a bioreactor and interpret the results  Understand and deploy strategies used for process optimization  Outline of cell culture in Cell Therapy Upstream processing 主辦單位：奇異亞洲醫療設備股份有限公司 協辦單位：財團法人生物技術開發中心

Cultivation Technology (CELL 2), TAIWAN 2017 Advanced Bioreactor Cultivation Technology (CELL 2), TAIWAN Lecture Topics  L1 From Cell Culture to Bioreactor  L2 Introduction into Wave and Xcellerex Bioreactors  L3 Cell Metabolism  L4 Process Control in Bioreactors  L5 Process Optimization  L6 Medium development  L7 Process Evaluation  L8 Culture Scale-Up and Technical Transfer  L9 Cell culture technology for Gene Therapy, Cell Therapy, and Vaccine production  L10 Cost benefit analysis of single use platform for mAb & vaccine manufacturing  L11 Harvest and clarification  L12 Validation of cell culture based processes Day 1 Day 2 Day 3 Day 4 AM am-1 L1 L4 L8 L11   am-2 L2 L5 G2 L12 am-3 P1 L6 P5 Lunch PM pm-1 L3 L7 L9 pm-2 P2 G1 L10 pm-3 P3 P4 REGISTER link: http://sc.ge.com/*cell2_2017tw

REGISTER link: http://sc.ge.com/*cell2_2017tw Practical Topics  P1 Lab Tour  P2 Sampling WAVE 25 (seed train for XDR 50) Cell Counting & Metabolism Analysis Setup XDR 50 bioreactor, Calibrate DO/pH probes Inflate XDR50 bag Aseptic transfer culture medium, equilibration of bioreactor  P3 Sampling WAVE 25 Inoculate XDR 50 bioreactor Set up the culture parameters and start XDR 50 cultivation  P4 Sampling XDR50 bioreactors Metabolite analysis and feed for XDR50  P5 Calculate specific nutrient consumption. Based on data, design composition of feed concentrate. Group Work  G1 Generic strategy for feed design … Calculate growth rates, viable cell integral, specific volumetric productivity, calculate cell specific nutrient consumption, based on this data, design composition of feed concentrate  G2 Generic calculate for scale-up … Considerations for process transfer to a bioreactor Design a production schedule and select an appropriate reactor size for scale up REGISTER link: http://sc.ge.com/*cell2_2017tw

global reach, Fast Trak At the speed of With GE’s worldwide Global centers footprint, you not only go faster to market, you can also go further. GE Fast Trak is a global organization with over 80 scientists. These, in turn, have access to hundreds more GE scientists and technology experts in related bioprocess fields, potentially giving you early access to innovations that may further speed you to market. Fast Trak portfolio of services  Analytical development/Quality control  Clinical manufacturing  Technology transfer  Training and education Turnkey bio-manufacturing solutions GE Healthcare Life Sciences 奇異亞洲醫療設備股份有限公司生命科學部