Early Brain Injury in Premature Newborns Detected with Magnetic Resonance Imaging is Associated with Adverse Early Neurodevelopmental Outcome Steven.

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Presentation transcript:

Early Brain Injury in Premature Newborns Detected with Magnetic Resonance Imaging is Associated with Adverse Early Neurodevelopmental Outcome Steven P. Miller, MD, Donna M. Ferriero, MD, Carol Leonard, PhD, Robert Piecuch, MD, David V. Glidden, PhD, J. Colin Partridge, MD, Marta Perez, BA, Pratik Mukherjee, MD, PhD, Daniel B. Vigneron, PhD, A. James Barkovich, MD The Journal of Pediatrics Volume 147, Issue 5, Pages 609-616 (November 2005) DOI: 10.1016/j.jpeds.2005.06.033 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 Cohort flow diagram. The Journal of Pediatrics 2005 147, 609-616DOI: (10.1016/j.jpeds.2005.06.033) Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 2 White matter injury on MRI. (A) Minimal white matter injury in a premature newborn born at 28 weeks gestational age and scanned at 2 weeks of life. The spoiled gradient echo volumetric scan shows a small focus of T1 hyperintensity (arrow) without cavitation in the right parietal periventricular white matter. This newborn also had IVH, a small retrocerebellar subdural hemorrhage (black arrow), and mild ventriculomegaly. (B) Moderate white matter injury in a premature newborn born at 30 weeks gestational age and scanned at 1 week of life. The spoiled gradient echo volumetric scan shows a moderate-sized focus of T1 hyperintensity (measuring > 2 mm involving < 5% of the hemisphere) without cavitation (arrow) in the left posterior periventricular white matter. (C) Severe white matter injuries in a premature newborn born at 30 weeks gestational age and studied at 2 weeks of life. The spoiled gradient echo volumetric scan demonstrates confluent areas of T1 hyperintensity (arrows) without cavitation throughout the periventricular white matter of both cerebral hemispheres. The Journal of Pediatrics 2005 147, 609-616DOI: (10.1016/j.jpeds.2005.06.033) Copyright © 2005 Elsevier Inc. Terms and Conditions