Fresh Frozen Plasma Modulates Brain Gene Expression in a Swine Model of Traumatic Brain Injury and Shock: A Network Analysis Martin Sillesen, MD, PhD,

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Fresh Frozen Plasma Modulates Brain Gene Expression in a Swine Model of Traumatic Brain Injury and Shock: A Network Analysis Martin Sillesen, MD, PhD, Ted Bambakidis, MSc, Simone E. Dekker, MD, Yongqing Li, MD, PhD, Hasan B. Alam, MD, FACS Journal of the American College of Surgeons Volume 224, Issue 1, Pages 49-58 (January 2017) DOI: 10.1016/j.jamcollsurg.2016.09.015 Copyright © 2016 American College of Surgeons Terms and Conditions

Figure 1 Comparisons of cluster eigenvectors, a vector indicating the overall direction and magnitude of the genes in (A) gene cluster A and (B) gene cluster B, between different resuscitation fluids. FFP, fresh frozen plasma; HEX, hetastarch; NS, normal saline. Journal of the American College of Surgeons 2017 224, 49-58DOI: (10.1016/j.jamcollsurg.2016.09.015) Copyright © 2016 American College of Surgeons Terms and Conditions

Figure 2 Graphical depiction of associations between gene eigenvectors for expression (A) clusters A and (B) cluster B, with clinical outcomes of brain swelling and brain lesion size. Journal of the American College of Surgeons 2017 224, 49-58DOI: (10.1016/j.jamcollsurg.2016.09.015) Copyright © 2016 American College of Surgeons Terms and Conditions

Figure 3 Plot of gene significance (defined as the absolute value of the correlation between the gene expression and presence or absence of fresh frozen plasma [FFP] resuscitation) vs module membership (defined as the absolute correlation between gene expression and the cluster eigenvector) in (A) cluster A and (B) cluster B. The observed high degree of correlation indicates that central genes in the identified module module also were highly associated with FFP resuscitation. Journal of the American College of Surgeons 2017 224, 49-58DOI: (10.1016/j.jamcollsurg.2016.09.015) Copyright © 2016 American College of Surgeons Terms and Conditions

Figure 4 Pathway analysis of up- and downregulated genes in clusters A and B. Journal of the American College of Surgeons 2017 224, 49-58DOI: (10.1016/j.jamcollsurg.2016.09.015) Copyright © 2016 American College of Surgeons Terms and Conditions