Radiotherapy treatment planning technology: present and future Joana Dias Inesc-Coimbra

Cancer represents an enormous burden on society in an ageing Europe, affecting a growing number of individuals and their relatives (…) Europe is characterized by worrying inequalities in cancer control and care existing within, as well as between, EU Member States European Commission

Treating cancer using radiation Radiotherapy Treating cancer using radiation At least 50% of cancer patients receive radiotherapy treatments There are several diferent treatment modalities: Intensity Modulated Radiation Therapy (IMRT) Volumetric Modulated Arc Therapy (VMAT) Protons Brachytherapy Como é que são planeados e administrados estes tratamentos?

Imagens médicas onde se vão delinear todas as estruturas de interesse.

Prescription Prescrição médica que determina limites às doses absorvidas

Treatment Modality Modalidades de tratamento-radiação externa

Treatment Modality Modalidades de tratamento-radiação externa

Increased computacional capacity Radiotherapy Recent advances: Increased computacional capacity Improvements in dose calculation (Monte Carlo simulation) Semiautomatic algorithms for image segmentation New treatment modalities

Objective: Making treatment planning fully automated Trial and error procedure Lengthy process Dependent on the planner experience and time availability Objective: Making treatment planning fully automated

Treatment planning

Every cancer patient in Europe will have access to state of the art radiation therapy, as part of a multidisciplinary approach where treatment is individualized for the specific patient’s cancer, taking into account of the patient’s personal circumstances. European Society for Radiotherapy & Oncology Vision 2020

Development of beam angle optimization algorithms Research developments in Inesc-Coimbra Development of beam angle optimization algorithms Fully automated fluence map optimization Multicriteria approaches Application to IMRT and VMAT Treatment complications prediction

Radiotherapy treatment planning optimization Future Medical prescription taking into account the specific patient’s features Personalized prediction of treatment outcomes and side effects (data mining, radiogenomics) Radiotherapy treatment planning optimization Mathematical models and optimization algorithms,, data mining, adaptive radiotherapy, motion prediction… Multicriteria analysis including patients’ preferences

Radiotherapy treatment planning technology: present and future Joana Dias Inesc-Coimbra