Effect of amarogentin on histamine and IFN-γ -induced MMP-1 production in human keratinocytes Histamine only slightly enhanced the production of MMP-1,

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Effect of amarogentin on histamine and IFN-γ -induced MMP-1 production in human keratinocytes Histamine only slightly enhanced the production of MMP-1, whereas IFN-γ increased synergistically this expression. Amarogentin as well as azelastine could inhibit the release of MMP-1 in histamine and IFN-γ co-stimulated HaCaT cells. Supplementary data 2 * * HaCaT cells were co-stimulated with 100 µM histamine and 200 U/ml interferon-γ (IFN-γ) and pre-incubated with amarogentin (100 µM) or azelastine (24 µM) for 30 minutes. After 24 h IL-8 expression was assessed in the cell supernatant (n=3) by Enzyme-Linked Immunosorbent Assay (ELISA) using a commercial kit from R&D Systems according to the manufacturer’s instructions.