Discriminatory and predictive capabilities of enzyme-linked immunosorbent assay and multiplex platforms in a longitudinal Alzheimer’s disease study  Wesley Jongbloed, Maartje I. Kester, Wiesje M. van der Flier, Robert Veerhuis, Philip Scheltens, Marinus A. Blankenstein, Charlotte E. Teunissen  Alzheimer's & Dementia: The Journal of the Alzheimer's Association  Volume 9, Issue 3, Pages 276-283 (May 2013) DOI: 10.1016/j.jalz.2012.01.004 Copyright © 2013 The Alzheimer's Association Terms and Conditions

Fig. 1 Bland–Altman plots of ELISA and xMAP data. Bland–Altman plots for Aβ42, Tau, and pTau depicting the effect of average biomarker concentrations (x-axis) on the ratio between ELISA and xMAP values (y-axis). A concentration-dependent effect is observed for all three biomarkers. ∗∗P < .01. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2013 9, 276-283DOI: (10.1016/j.jalz.2012.01.004) Copyright © 2013 The Alzheimer's Association Terms and Conditions

Fig. 2 Kaplan–Meier curves for each biomarker measured in ELISA and xMAP. Kaplan–Meier curves for Aβ42, Tau, and pTau for the conversion to Alzheimer’s disease within the group of mild cognitive impairment patients. Time (years) represents the time between the first lumbar puncture and follow-up diagnosis. Aβ42 levels below and Tau and pTau levels above the median are considered Alzheimer’s disease positive. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2013 9, 276-283DOI: (10.1016/j.jalz.2012.01.004) Copyright © 2013 The Alzheimer's Association Terms and Conditions