In-hospital switching of oral P2Y12 inhibitor treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention: Prevalence,

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In-hospital switching of oral P2Y12 inhibitor treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention: Prevalence, predictors and short-term outcome Dimitrios Alexopoulos, MD, Ioanna Xanthopoulou, MD, Spyridon Deftereos, MD, George Sitafidis, MD, Ioannis Kanakakis, MD, Michalis Hamilos, MD, Christos Angelidis, MD, Stylianos Petousis, MD, Dimitrios Stakos, MD, Haralambos Parissis, MD, Manolis Vavouranakis, MD, Periklis Davlouros, MD, John Goudevenos, MD, Christodoulos Stefanadis, MD American Heart Journal Volume 167, Issue 1, Pages 68-76.e2 (January 2014) DOI: 10.1016/j.ahj.2013.10.010 Copyright © 2014 Mosby, Inc. Terms and Conditions

Figure 1 Prevalence of in-hospital P2Y12 inhibitors use and switching. Switching occurred mostly in the form of changing from clopidogrel to ticagrelor (50.3%) or prasugrel (40.1%). American Heart Journal 2014 167, 68-76.e2DOI: (10.1016/j.ahj.2013.10.010) Copyright © 2014 Mosby, Inc. Terms and Conditions

Figure 2 Multivariate analysis of predictive factors of switching to a novel P2Y12 inhibitor in patients who were initially treated with clopidogrel. CABG, Coronary artery bypass grafting; COPD, chronic obstructive pulmonary disease; CrCl, creatinine clearance; RR, relative risk; STEMI, ST-elevation myocardial infarction; TIA, transient ischemic attack. American Heart Journal 2014 167, 68-76.e2DOI: (10.1016/j.ahj.2013.10.010) Copyright © 2014 Mosby, Inc. Terms and Conditions

Figure 3 Patients analyzed at follow-up. Propensity-matched pairs were created among 524 patients with in-hospital switching to a novel P2Y12 inhibitor, 633 clopidogrel only, and 460 prasugrel or ticagrelor only treated patients. American Heart Journal 2014 167, 68-76.e2DOI: (10.1016/j.ahj.2013.10.010) Copyright © 2014 Mosby, Inc. Terms and Conditions

Figure 4 Percentage standardized differences in patients’ characteristics before and after propensity score matching who either switched from clopidogrel to ticagrelor/prasugrel, or were only ticagrelor/prasugrel treated (A) and either switched from clopidogrel to ticagrelor/prasugrel or were only clopidogrel treated (B). MI, myocardial infarction; FMC, first medical contact; CrCl, creatinine clearance; COPD, chronic obstructive pulmonary disease. American Heart Journal 2014 167, 68-76.e2DOI: (10.1016/j.ahj.2013.10.010) Copyright © 2014 Mosby, Inc. Terms and Conditions