An Introduction To The Health Effects of Caffeine April 17, 2018 A Small Dose of ™ Caffeine An Introduction To The Health Effects of Caffeine A Small Dose of Caffeine

What Is This? O CH3 CH3 N N N O N CH3 7 1 3 April 17, 2018 A Small Dose of Caffeine

Caffeine – 1,3,7 Trimethylxanthine April 17, 2018 Caffeine – 1,3,7 Trimethylxanthine O CH3 CH3 N N 7 1 3 N O N CH3 A Small Dose of Caffeine

History of Coffee Date Event April 17, 2018 History of Coffee Date Event ~850 - Coffee beans discovered - The fable says that an Ethiopian goat or sheepherder noticed that the goats were more alter after eating the wild berries. He then sampled this new delicacy. ~1100 - First coffee trees and roasting of coffee beans. 1475 - Constantinople – the world’s first coffee house. 1600s - Coffee enters Europe and moves quickly to the Americas 1700s - Coffee house open throughout Europe. 1723 - First coffee plants are introduced into the Americas. 1822 - First espresso machine is created in France. 1938 - First instant coffee invented by the Nestlé company. 1971 - Starbucks opens its first location in Seattle, Washington's Pike Place Market. A Small Dose of Caffeine

April 17, 2018 Caffeine & Money The coffee and cola industries owe their wealth to the physiological properties of the drug caffeine. S.G. Gilbert (2001) A Small Dose of Caffeine

History of Tea Date Event April 17, 2018 History of Tea Date Event 3000 B.C. - Tea discovered in China or introduced form India 350 B.C. - First written description of Tea drinking in China. 450 A.D. - Turkish traders bargain for Tea and the Silk road is born. 800 - Tea introduced to Japan. 1450 - Japanese Tea ceremony created and popularized 1610 - Dutch bring Tea to Europe 1773 - Boston Tea party, rebellion against England’s tea tax 1776 - England sends first Opium to China to help pay for tea. 1835 - First experimental tea plantations in Assam, India. 1908 - Tea bags invented in New York. A Small Dose of Caffeine

History of Chocolate Date Event April 17, 2018 History of Chocolate Date Event 400 B.C. - Olmec people of Mexico made chocolate drinks 250 A.D. - Mayans of Mexico were cultivating cocoa crops 1528 - Cocoa was brought to Spain by Hernando Cortés 1600s - Chocolate drinks introduced into Europe 1657 - First English chocolate houses open 1828 - Screw press that extracted the cocoa butter from the beans invented in Holland 1840s - Chocolate as solid developed A Small Dose of Caffeine

Quote – Lovers of Coffee April 17, 2018 Quote – Lovers of Coffee Coffee Black as hell, strong as death, sweet as love. Turkish proverb. A Small Dose of Caffeine

April 17, 2018 Quote – Fear of Coffee "Often coffee drinkers, finding the drug to be unpleasant, turn to other narcotics, of which opium and alcohol are most common.“ Morphinism and Narcomanias from Other Drugs (1902) by T. D. Crothers, M.D. A Small Dose of Caffeine

April 17, 2018 Quote – Love of Tea “Tea, though ridiculed by those who are naturally coarse in their nervous sensibilities … will always be the favorite beverage of the intellectual.” Thomas De Quincey (1785–1859), English author. Confessions of an English Opium-Eater,“The Pleasures of Opium” (1822). A Small Dose of Caffeine

Quote – Religion and Drugs April 17, 2018 Quote – Religion and Drugs If Christianity is wine, and Islam coffee, Buddhism is most certainly tea. Alan Watts, The Way of Zen, 1957 A Small Dose of Caffeine

Historical Events Tea trade and opium Opium War of 1839-42 April 17, 2018 Historical Events Tea trade and opium Opium War of 1839-42 Great Britain has a monopoly on the sale of opium which it forces on China; eventually gaining control of Hong Kong. Consider our societies ongoing “war on drugs”. A Small Dose of Caffeine

Caffeine and Society Most widely consumed stimulant drug in the world April 17, 2018 Caffeine and Society Most widely consumed stimulant drug in the world Many people start consuming caffeine at an early age A great deal of money is made from caffeine – why? A Small Dose of Caffeine

Most widely consumed neuroactive compound April 17, 2018 Exposure Most widely consumed neuroactive compound Coffee Soda Products Tea Chocolate A Small Dose of Caffeine

Caffeine Content 1 Cup of coffee – 65-175 mg 1 Cup of tea – 50 mg April 17, 2018 Caffeine Content 1 Cup of coffee – 65-175 mg 1 Cup of tea – 50 mg Can of soda (12 oz) – 40-50 mg Bar of chocolate (30 g) – 1-35 mg A Small Dose of Caffeine

Have you every drank too much caffeine? April 17, 2018 Exposure and Effects Have you every drank too much caffeine? What are the effects? A Small Dose of Caffeine

Aspects of Caffeine Desirable effects April 17, 2018 Aspects of Caffeine Desirable effects Stimulant, increased alertness, concentrate, energy, bronchial dilator Toxicity Restlessness, jitters, anxiety, insomnia, elevated or irregular heart rate No tolerance Most develop little or no tolerance to the nervous system effects Withdrawal effects Transient but persistent, headache, low energy, in ability to concentrate A Small Dose of Caffeine

Absorption Rapidly absorbed following oral consumption April 17, 2018 Absorption Rapidly absorbed following oral consumption Peak blood (plasma) levels usually with 30 minutes A Small Dose of Caffeine

Distribution Does not accumulate April 17, 2018 Distribution Distributes into all body compartments – Pass easily into brain, breast milk and crosses placenta Does not accumulate A Small Dose of Caffeine

Metabolism/Elimination April 17, 2018 Metabolized in the liver Changed to di- and mon- methylxanthines Excreted in the urine A Small Dose of Caffeine

Half-life How long it takes to leave the body Average adult – 3-5 hrs April 17, 2018 Half-life How long it takes to leave the body Average adult – 3-5 hrs Child less that 6 months – 24 hrs Pregnant – 7-8 hrs Smoker – 2-3 hrs Varies between individuals A Small Dose of Caffeine

Theophylline – 1,3 Dimethylxanthine April 17, 2018 Theophylline – 1,3 Dimethylxanthine O H CH3 N N 7 1 3 N O N CH3 A Small Dose of Caffeine

Blocks Adenosine receptor Adenosine is a calming neurotransmitter April 17, 2018 Mechanism Of Action Blocks Adenosine receptor Adenosine is a calming neurotransmitter A Small Dose of Caffeine

Parents Of Caffeine PURINE XANTHINE April 17, 2018 Parents Of Caffeine PURINE XANTHINE Parent of compounds found in RNA & DNA Dioxypurine - Parent methylxanthines A Small Dose of Caffeine

Normal Action of Adenosine Adenosine Receptor 1 Adenosine Outside Cell Cell Membrane 2 Inside Cell Adenosine binds to receptor 3 Signal Protein Positive Response Calming effect

Action of Caffeine 1 2 3 Caffeine Adenosine Receptor Caffeine inactivates receptor 3 Adenosine can not bind Caffeine No Response Resulting in Stimulation

Why so many $$s from caffeine? April 17, 2018 Why so many $$s from caffeine? Pleasant stimulant effects Short Half-life (you need to back for more) Can’t drink too much at any one time (toxicity) Headache when you stop drinking it A Small Dose of Caffeine

A Small Dose of ™ Caffeine April 17, 2018 A Small Dose of ™ Caffeine A Small Dose of Caffeine

Additional Information April 17, 2018 Additional Information Web Sites England – Department of Health – Statement on the reproductive effects of caffeine. Online. <http://www.doh.gov.uk/sacn/pdf/200106caffeine.pdf> (accessed: 2 April 2003). U.S. Food and Drug Administration (FDA) - Perplexities Of Pregnancy. Online. <http://www.cfsan.fda.gov/~dms/wh-preg2.html> (accessed: 9 April 2003). Caffeine – The Vaults of Erowid. Online. <http://www.erowid.org/chemicals/caffeine/caffeine.shtml> (accessed: 2 April 2003). A Small Dose of Caffeine

Authorship Information April 17, 2018 Authorship Information This presentation is supplement to “A Small Dose of Toxicology” For Additional Information Contact Steven G. Gilbert, PhD, DABT E-mail: smdose@asmalldoseof.org Web: www.asmalldoseof.org A Small Dose of Caffeine

Xanthine O H H N N N O N H 7 1 3 April 17, 2018 A Small Dose of Caffeine

April 17, 2018 Purine H N N 7 1 3 N N A Small Dose of Caffeine