APOE and aging-related cognitive change in a longitudinal cohort of men Ville Rantalainen, Jari Lahti, Markus Henriksson, Eero Kajantie, Pentti Tienari,

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APOE and aging-related cognitive change in a longitudinal cohort of men Ville Rantalainen, Jari Lahti, Markus Henriksson, Eero Kajantie, Pentti Tienari, Johan G. Eriksson, Katri Raikkonen Neurobiology of Aging Volume 44, Pages 151-158 (August 2016) DOI: 10.1016/j.neurobiolaging.2016.04.024 Copyright © 2016 Elsevier Inc. Terms and Conditions

Fig. 1 Estimated marginal means for cognitive ability total and subtest scores at 67.6 years according to the number of minor alleles in rs405509 (A) and rs440446 (B) polymorphisms. Error bars represent standard errors. The p-values are adjusted for APOE major isoforms, age at cognitive testing, maximum attained lifetime occupational status, and population stratification. Cognitive ability scores are standardized to mean = 100, standard deviation = 15. Neurobiology of Aging 2016 44, 151-158DOI: (10.1016/j.neurobiolaging.2016.04.024) Copyright © 2016 Elsevier Inc. Terms and Conditions

Fig. 2 Change in cognitive ability total and subtest scores between 20.1 and 67.6 years according to the number of minor alleles in rs405509 and rs440446 polymorphisms. Bars represent change scores, error bars represent standard errors. The p-values are adjusted for APOE major isoforms, age at cognitive testing, maximum attained lifetime occupational status, and population stratification (A and C), and in APOE ε3/3 homozygotes for age at cognitive testing, maximum attained lifetime occupational status, and population stratification (B and D). Neurobiology of Aging 2016 44, 151-158DOI: (10.1016/j.neurobiolaging.2016.04.024) Copyright © 2016 Elsevier Inc. Terms and Conditions

Supplementary Figure 1 Change in cognitive ability total and subtest scores between 20.1 and 67.6 years in APOE ε3/3, ε2/3 and ε4/2, ε4/3 and ε4/4 carriers. Bars represent change scores, error bars represent standard errors. The p-values are adjusted for age at cognitive testing, maximum attained lifetime occupational status, and population stratification. The p-value before slash compares APOE ε3/3 versus ε2/3. The p-value after slash compares APOE ε3/3 versus ε4/2, ε4/3 and ε4/4. Neurobiology of Aging 2016 44, 151-158DOI: (10.1016/j.neurobiolaging.2016.04.024) Copyright © 2016 Elsevier Inc. Terms and Conditions