Volume 76, Issue 4, Pages 507-511 (April 2011) A hypothetical relationship between the nuclear reprogramming factors for induced pluripotent stem (iPS) cells generation – bioinformatic and algorithmic approach  Sanjiban Sekhar Roy, C.H. Hsu, Z.H. Wen, C.S. Lin, Chiranjib Chakraborty  Medical Hypotheses  Volume 76, Issue 4, Pages 507-511 (April 2011) DOI: 10.1016/j.mehy.2010.12.003 Copyright © 2010 Elsevier Ltd Terms and Conditions

Fig. 1 Alignment scores of protein sequences of nuclear reprogramming factors for iPS development. (A) Alignment score between sequences (notation Seq (x:y) meaning alignment score between sequence x, and sequence y). (B) Scatter distribution of scores. (C) Scores connected by smoothed line without marker. Medical Hypotheses 2011 76, 507-511DOI: (10.1016/j.mehy.2010.12.003) Copyright © 2010 Elsevier Ltd Terms and Conditions

Fig. 2 Phylogenetic tree construction using Phylogeny.fr software. (A) Phylogram of four factors which are having sequence alignments score ⩾10. (B) Cladogram of four factors which are having sequence alignments score ⩾10. Medical Hypotheses 2011 76, 507-511DOI: (10.1016/j.mehy.2010.12.003) Copyright © 2010 Elsevier Ltd Terms and Conditions

Fig. 3 Phylogenetic tree for algorithm analysis. (A) Cladogram of four factors for tree algorithm analysis. (B) Representation binary tree equivalent to Cladogram. Medical Hypotheses 2011 76, 507-511DOI: (10.1016/j.mehy.2010.12.003) Copyright © 2010 Elsevier Ltd Terms and Conditions

Fig. 4 Scheme showing the hypothetical relationship between the nuclear reprogramming factors for induced pluripotent stem (iPS) cells generation. Medical Hypotheses 2011 76, 507-511DOI: (10.1016/j.mehy.2010.12.003) Copyright © 2010 Elsevier Ltd Terms and Conditions