From: General Anesthetic-induced Seizures Can Be Explained by a Mean-field Model of Cortical Dynamics Anesthes. 2006;104(3):588-593. Figure Legend: Fig. 2. A diagram of the stability of the modeled cortex as increasing concentrations of enflurane and isoflurane are applied.  b  shows a three-dimensional plot of the steady state excitatory neuronal soma potential. The  dark shading  and  light shading  denote stable (awake or anesthetized) and unstable (seizure) states, respectively.  a  shows a two-dimensional plan view of  b  . The trajectory of increasing concentrations (X = 1 minimum alveolar concentration50) of enflurane) is shown by the  dashed line  , and the trajectory of isoflurane is shown by the  solid line  .The  insets  show the (inverted) shape of the inhibitory postsynaptic potential (IPSP) at the points denoted by the  square  and  diamond  . Date of download: 10/6/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.