Feasibility and Efficacy of Percutaneous Transcatheter Intraarterial Chemotherapy with Paclitaxel in Albumin Nanoparticles for Advanced Squamous-Cell.

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Feasibility and Efficacy of Percutaneous Transcatheter Intraarterial Chemotherapy with Paclitaxel in Albumin Nanoparticles for Advanced Squamous-Cell Carcinoma of the Oral Cavity, Oropharynx, and Hypopharynx Bruno Damascelli, MD, Gianluigi Patelli, MD, Vladimira Tichá, MD, Giuseppe Di Tolla, MD, Laura F. Frigerio, MD, Francesco Garbagnati, MD, Rodolfo Lanocita, MD, Alfonso Marchianò, MD, Carlo Spreafico, MD, Franco Mattavelli, MD, Andrea Bruno, MD, Franco Zunino, MD Journal of Vascular and Interventional Radiology Volume 18, Issue 11, Pages 1395-1403 (November 2007) DOI: 10.1016/j.jvir.2007.06.009 Copyright © 2007 SIR Terms and Conditions

Figure 1 SCC of margin of right gum. Pretreatment photograph (a) and CT image (b) of the tumor. (c) FDG PET depicts metabolic activity of the tumor. (d) Digital subtraction angiography performed through the guide catheter shows the position of the microcatheter in the right external carotid artery below the lingual and facial trunk. (e) Posttreatment photograph shows reduction of mass. (f) CT image obtained after 3 cycles of intraarterial chemotherapy with ABI-007. (g) Viable tumor residue is shown on FDG PET. (h) Digital subtraction angiography of the external carotid artery at the end of treatment shows the integrity of the vascular walls (arrow, facial artery). (Available in color online at www.jvir.org.) Journal of Vascular and Interventional Radiology 2007 18, 1395-1403DOI: (10.1016/j.jvir.2007.06.009) Copyright © 2007 SIR Terms and Conditions

Figure 2 (a) SCC of the left tonsil seen on CT. (b) Tumor metabolic activity is well depicted by FDG PET. (c) CT shows complete radiologic response at the end of treatment. (d) FDG PET shows lack of metabolic activity in the left tonsillar fossa. (Available in color online at www.jvir.org.) Journal of Vascular and Interventional Radiology 2007 18, 1395-1403DOI: (10.1016/j.jvir.2007.06.009) Copyright © 2007 SIR Terms and Conditions

Figure 3 (a) Photograph of SCC lesion of the right margin of the tongue on presentation. (b) Histologic findings in the surgical specimen. (c) Photograph after three cycles of intraarterial chemotherapy with ABI-007. (d) Microscopic residual disease is visible at a magnification of 400. Note the absence of mucositis. Journal of Vascular and Interventional Radiology 2007 18, 1395-1403DOI: (10.1016/j.jvir.2007.06.009) Copyright © 2007 SIR Terms and Conditions