Feifei Teng, Christina I. Tsien, Theodore S. Lawrence, Yue Cao

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Blood–tumor barrier opening changes in brain metastases from pre to one-month post radiation therapy Feifei Teng, Christina I. Tsien, Theodore S. Lawrence, Yue Cao Radiotherapy and Oncology DOI: 10.1016/j.radonc.2017.08.006 Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 1 Post-contrast T1-weighted images and Ktrans maps from a low-permeability tumor and a high-permeability tumor pre-RT, 2-weeks during WBRT and 1mo post-RT. Cyan, magenta, and red contours represent enhanced GTV, and the volumes with Ktrans>0.005 and >0.037min−1, respectively. Radiotherapy and Oncology DOI: (10.1016/j.radonc.2017.08.006) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 2 Mean values (±SEM) of %Vall (a), %Vlow (b) and %Vhigh (c) of low-permeability and high-permeability tumors received WBRT and SRS pre-RT, 1–2weeks after starting RT and 1mo post-RT. Radiotherapy and Oncology DOI: (10.1016/j.radonc.2017.08.006) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 3 Mean values (±SEM) of %Vall in low-permeability tumors (n=7), and high-permeability tumors (n=10) from the same 6 patients. Radiotherapy and Oncology DOI: (10.1016/j.radonc.2017.08.006) Copyright © 2017 Elsevier B.V. Terms and Conditions

Supplementary Figure 1 Radiotherapy and Oncology DOI: (10.1016/j.radonc.2017.08.006) Copyright © 2017 Elsevier B.V. Terms and Conditions