Candidate locus analysis of familial ascending aortic aneurysms and dissections confirms the linkage to the chromosome 5q13-14 in Finnish families Sakari.

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Candidate locus analysis of familial ascending aortic aneurysms and dissections confirms the linkage to the chromosome 5q13-14 in Finnish families Sakari Kakko, MD, PhD, Tuija Räisänen, MSc, Minna Tamminen, MD, PhD, Juhani Airaksinen, MD, PhD, Kaj Groundstroem, MD, PhD, Tatu Juvonen, MD, PhD, Antti Ylitalo, MD, PhD, Paavo Uusimaa, MD, PhD, Markku J Savolainen, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 126, Issue 1, Pages 106-113 (July 2003) DOI: 10.1016/S0022-5223(03)00037-0

Figure 1 The pedigrees of the FTAAD families participating in the study. The study subjects genotyped are numbered with Arabic numbers, whereas family members not genotyped are numbered with Roman numbers. Three subjects with abdominal aortic aneurysms (subject V in the family 5, subject X in the family 7, and subject VIII in the family 8) were coded to have unknown phenotype in the analysis, but are marked as affected in the figure. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 106-113DOI: (10.1016/S0022-5223(03)00037-0)

Figure 2 Multipoint NPL scores and LOD scores of dominant model for the chromosomal locus 5q13-14. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 106-113DOI: (10.1016/S0022-5223(03)00037-0)

Figure 3 The haplotypes of markers at chromosomal location 5q13-14 for families 4 and 7 with the highest NPL scores. The subject X in family 7 has abdominal aortic aneurysm (AAA). The Journal of Thoracic and Cardiovascular Surgery 2003 126, 106-113DOI: (10.1016/S0022-5223(03)00037-0)