9th IAS CONFERENCE ON HIV SCIENCE PARIS, FRANCE JULY

Slides:

Advertisements

Similar presentations

Outcomes of Five Years of Planned Home Birth Attended by Regulated Midwives vs. Planned Hospital Birth in British Columbia P Janssen, PhD, 1,2,4,5, MC.

Advertisements

PMTCT FAILURE: THE ROLE OF MATERNAL AND FACILITY –RELATED FACTORS ICASA Presentation 8 th to 12 th Dec 2013 Onono Maricianah 1, Elizabeth A. Bukusi 1,

PMTCT program in Arua Uganda Lessons learned after 5 years of experience Experts Roundtable June 2008 Geneva.

FACTORS ASSOCIATED WITH BREASTFEEDING RATES AT BIRTH AND DISCONTINUATION BEFORE ONE MONTH, FRANCE, 2012 Benoit SALANAVE, Catherine De LAUNAY, Caroline.

Growth Assessment Protocol

Associations between gestational weight gain and child BMI at age 5 Author 1 Author 2 December 5, 2007 PH 251.

Feedback from Pregnancy research group UK CHIC / UK HIV Drug Resistance Database Meeting, 2 July 2010 Pregnancy Group: Jane Anderson, Loveleen Bansi, Susie.

Presenter : Dr T. G. Nematadzira on behalf of The IMPAACT PROMISE 1077BF/1077FF Team Efficacy and Safety of Two Strategies to Prevent Perinatal HIV Transmission.

Using Virginia PRAMS data to assess the impact of WIC and Home Visiting Programs on birth outcomes August 10, 2011 Monisha Shah GSIP Intern.

Population-based impact of ART in high HIV prevalence settings Marie-Louise Newell Professor of Global Health Faculty of Medicine, Faculty of Social and.

Older and wiser: continued improvements in clinical outcome and highly active antiretroviral therapy (HAART) response in HIV-infected children in the UK.

Catherine Kober Margaret Johnson Martin Fisher Caroline Sabin On behalf of UK-CHIC BHIVA/BASHH Manchester 2010 Non-uptake of HAART among patients with.

Data from the Collaborative HIV Paediatric Study (CHIPS) Reports up to May 2005.

Maternal weight and the obesogenic environment in Nova Scotia Sara Kirk, Louise Parker, Trevor Dummer, Linda Dodds, Tarra Penney.

Stillbirths in Scotland: Inequalities Lessening? Leslie Marr Manager, Reproductive Health Programme.

Is Highly Active Antiretroviral Therapy (HAART) in pregnancy protective against maternal mortality? Results from a large DREAM cohort in Malawi and Mozambique.

Immune Discordance on Highly Active Antiretroviral Therapy Can Still be Regarded as a Therapeutic Success Nur F. Önen MD, MRCP 1, Rachel Presti MD PhD.

Data from the Collaborative HIV Paediatric Study (CHIPS) Reports up to March 2006* *Numbers are based on reports received rather than children seen to.

Task-shifting of HIV care and ART initiation: Three year evaluation of a mixed-care provider model for ART delivery Megan McGuire 1, Jihane Ben-Farhat.

Outcomes of Antiretroviral Treatment Programs in Rural Lesotho: Health Centers and Hospitals Compared Niklaus Labhardt, Motlalepula Sello, Mamokone A.

ЗДОРОВЪЕ SHENDET здоров'я ЗДРАВЉЕ ZDRAWIE ZDRAVLJE ZDRAVÍ ЗДОРОВЪЕ Pregnancy Outcomes Among Immigrant Women from Eastern Europe and the CIS in New York.

Factors associated with maternal smoking during early pregnancy: relationship to low-birth-weight infants and maternal attitude toward their pregnancy.

Effect of ART on malaria parasitaemia and clinical episodes in adults in rural Uganda: A population-based cohort study Billy N. Mayanja 1, Kathy Baisley.

First-Line Treatment of HIV Infection With Either NNRTI- or PI-Based Regimens Effective for Long-term Disease Control Slideset on: MacArthur RD, Novak.

1 Predictors of virological failure in a Cambodian setting Sokkab An, M.D Sihanouk Hospital Center of HOPE (SHCH), Phnom Penh, Cambodia.

Preeclampsia and Retinopathy of prematurity in Very-Low-Birth-Weight-Infants − A population base study Hsin-Chung Huang 1, Hwai-I Yang 2, Wu-Shiun Hsieh.

National data bases and classification of death in Sweden Sven Cnattingius, MD, PhD.

Trends in maternal deaths in HIV-infected women, on a background of changing HIV management guidelines in South Africa: 1997 to ,2,3CN Mnyani, 1EJ.

Factors associated with loss to follow up in a primary healthcare clinic practicing test and treat Authors: Julius Kiwanuka1,2, Noah Kiwanuka3, Flavia.

Incidence of tuberculosis in the first year of antiretroviral treatment in West-African HIV-infected adults B. Tchakounte Youngui1, P. Coffie2, E. Messou3,

Timalsina U, Sharma S, Giri S, Basyal B, Bhandari S, Neupane M

UOG Journal Club: July 2016 Ability of a preterm surveillance clinic to triage risk of preterm birth: a prospective cohort study J Min, HA Watson, NL Hezelgrave,

ADVERSE OUTCOMES OF TREATING HIV-TB

OVERVIEW OF PREVENTING MOTHER TO CHILD TRANSMISSION OF HIV

Pregnancy and living with HIV

Inonu University, Turgut Ozal Medical Centre

Progress Report Moscow Region Infant Study

Vital statistics in obstetrics.

Preterm birth < 37 weeks

Figure 1 Inclusion criteria, exclusion criteria, and criteria for virologic failure. CDC, Centers for Disease Control and Prevention; ddC, zalcitabine;

Factors affecting virological failure in patients receiving antiretroviral therapy: a prospective HIV Clinical cohort in rural Uganda. Patrick Kazooba1,

Birth Weight and Preterm Delivery Outcomes of Perinatally vs

Keerti Singh, C Greaves, L Mohammed, A Kumar.

Madonna Murphy Newfoundland and Labrador Centre for Health Information

Obstetric and paediatric HIV surveillance data from the UK and Ireland

HIV surveillance in Northern Ireland 2015

Maternal Factors and Risk of Late Preterm Delivery

Better Retention Rates Observed in Patients on Lopinavir than Atazanavir in Uganda

Introduction Materials and Methods Results Conclusions

Maternal health and early years

Table 1: New HIV diagnoses, by UK country,

Obstetric and paediatric HIV surveillance data from the UK and Ireland

Obstetric and paediatric HIV surveillance data from the UK and Ireland

Children’s Health in Northern Ireland

Children’s Health in Northern Ireland

Obstetric and paediatric HIV surveillance data from the UK and Ireland

January 2014 Update Obstetric and paediatric HIV surveillance data from the UK and Ireland.

Results from the 2015 Perinatal Confidential Enquiry

HIV/AIDS Surveillance in Europe 2011

Dorina Onoya1, Tembeka Sineke1, Alana Brennan1,2, Matt Fox1,2

Cepheid Symposium, IAS 23rd July 2018

Long-Term Clinical and Immunologic Outcomes Are Similar in HIV-Infected Persons Randomized to NNRTI versus PI versus NNRTI+PI-based Antiretroviral Regimens.

Children’s Health in Northern Ireland

Volume 377, Issue 9777, Pages (May 2011)

Breastfeeding Initiation: Impact of Obesity in a Large Canadian Perinatal Cohort Study Julie Verret-Chalifour, Yves Giguere, Jean-Claude Forest, Jordie.

Pregnancy outcomes in kidney transplant recipients

Andreas D. Haas, PhD Postdoctoral fellow, ICAP at Columbia University

Share your thoughts on this presentation with #IAS2019

Chantal Nelson BORN Annual Conference April 25, 2017

Volume 13, Pages (August 2019) Predictors of Ischemic and Hemorrhagic Strokes Among People Living With HIV: The D:A:D International Prospective.

Presentation transcript:

9th IAS CONFERENCE ON HIV SCIENCE PARIS, FRANCE 23-26 JULY Stillbirth in HIV-infected women delivering in UK/Ireland between 2007 and 2015 G. Favarato, R.Sconza, H. Peters, A. Horn, K.Francis, H. Bailey, P. Tookey, C. Thorne UCL Great Ormond Street Institute of Child Health, London, UK 9th IAS CONFERENCE ON HIV SCIENCE PARIS, FRANCE 23-26 JULY

Background Aim Study design: Causes of stillbirth (SB) are multifactorial and incompletely understood In UK/Ireland previously reported higher SB rate in HIV+ women Aim To explore current SB rate and associated risk factors in HIV+ women delivering in UK/Ireland using data from a national surveillance study Study design: Pregnancies in HIV+ women reported to the National Study on HIV in Pregnancy and Childhood (NSHPC) in 2007-2015 Inclusion: singleton delivered at ≥ 24 gestational weeks (GW) Definition of SB: an infant delivered at ≥24 (GW) showing no signs of life Statistical analysis: multivariable Poisson regression

Characteristics: pregnancies SB/TOTAL % SB 89/10405 0.9 Delivery year 2007-2009 41/3884 1.1 2010-2012 30/3621 0.8 2013-2015 18/2900 0.6 Region of origin Europe/WEWC 8/2004 0.4 SSA 71/7752 Other 7/528 1.3 Maternal age <28 years 12/2249 0.5 28-32 years 23 /2494 33-36 years 28 /2848 1.0 >36 years 26 /2814 SB/TOTAL % SB Parity Primiparous 30/2698 1.1 Multiparous 50/7197 0.7 CD4 count cells/mm3 >350 38/6407 0.6 ≤350 41/3360 1.2 Antenatal ART based regimen PI/r- 48/5454 0.9 NNRTI- 21/2427 INSTI- 2/120 1.7 Other 0/335 0.0 Switched 11/1615 SB=stillbirth; WEWC= westernised countries; SSA= sub-Saharan countries; PI/r= ritonavir boosted protease inhibitors; NNRTI=non-nucleoside reverse transcriptase inhibitors; INSTI=integrase inhibitors

Characteristics: Stillbirth (SB) infants Compared to live-born infants, SB more likely: Born pre-term: Median gestation weeks: 33 (IQR 27-37) vs 39 (38-40) Very preterm (<34 GW): 46/89 (52%) vs 409/10302 (4%) Small for gestational age1 (SGA): 28/62 (55%) vs. 2208/7774 (21% To be of male gender: 39/67 (58%) vs. 5164/10290 (50%) Have congenital abnormalities: 9/61 (15%) vs. 285/10000 (3%) 1 Based on sex-specific US standard

Conclusions Risk factors for SB Significant risk factors for SB from multivariable analysis: antenatal CD4 count ≤350cells/µL IRR 1.73 [95% CI 1.05, 2.86] primiparity IRR 1.85 [1.10, 3.12] older age in women >36yr vs women <28 years, IRR 4.12 [1.49, 11.35] SSA origin IRR 3.26 [1.07, 9.95] or other world region IRR 5.59 [1.46, 21.48] vs Europe/WEWC. Conclusions SB rate (0.9%) higher than that in UK general population (~0.4%) Study limitations: no routine data collection for some risk factors for SB (e.g. SES, smoking, BMI) unable to classify SB as antepartum vs intrapartum Future work enhanced data collection within an embedded audit of pregnancies ending in SB to standardise SB rate by maternal origin