Volume 66, Issue 4, Pages (October 2004)

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Volume 66, Issue 4, Pages 1654-1661 (October 2004) Patient and graft outcomes from older living kidney donors are similar to those from younger donors despite lower GFR Lourdes S.Peña De La Vega, Alvaro Torres, Humberto E. Bohorquez, Julie K. Heimbach, James M. Gloor, Thomas R. Schwab, Sandra J. Taler, Scott L. Nyberg, Michael B. Ishitani, Mikel Prieto, Jorge A. Velosa, Timothy S. Larson, Mark D. Stegall, Fernando G. Cosio, Stephen C. Textor, Matthew D. Griffin Kidney International Volume 66, Issue 4, Pages 1654-1661 (October 2004) DOI: 10.1111/j.1523-1755.2004.00932.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Recipients of older and younger living donor kidney transplants have similar graft and patient survival to three years' post-transplant. Kaplan Meier survival curves between 0 to 36 months' post-transplant are shown for overall graft survival (upper), patient survival (lower left), and death-censored graft survival (lower right) of patients receiving living donor kidney transplant from donors aged less than 50 years (dashed lines) or donors aged 50 years or greater (solid lines). For all three survival indices, no significant differences are present between the two groups. Kidney International 2004 66, 1654-1661DOI: (10.1111/j.1523-1755.2004.00932.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 Recipients of older living donor kidney transplants have higher average serum creatinine concentration and lower average glomerular filtration rate (GFR) compared to recipients of younger living donor kidney transplants. Serum creatinine concentrations (A) and iothalamate clearances (B) are shown for recipients of living donor kidney transplants from donors aged less than 50 years (gray circles) or donors aged 50 years or greater (black circles). Results at 1, 12, and 24 months post-transplantation are expressed as mean ± SD, and the number of patients for which results were available at each time point is indicated. †P < 0.05 for older donor recipients vs. younger donor recipients. Kidney International 2004 66, 1654-1661DOI: (10.1111/j.1523-1755.2004.00932.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 3 Recipient glomerular filtration rate (GFR) is inversely correlated with living donor age at 1, 12, and 24 months post-transplant. The relationship between living donor age and recipient GFR (iothalamate clearance corrected for body surface area) is shown as linear regression plots of available results for the entire study population at 1, 12, and 24 months post-transplant. At each time point following transplantation a significant inverse correlation between donor age and GFR was evident. Kidney International 2004 66, 1654-1661DOI: (10.1111/j.1523-1755.2004.00932.x) Copyright © 2004 International Society of Nephrology Terms and Conditions