Features of adult GH deficiency Improved by GH replacement? Features of adult growth hormone (GH) deficiency syndrome and response to therapy (adapted from Reference 65 and other sources) Features of adult GH deficiency Improved by GH replacement?  Fat mass (especially abdominal fat)‏ Yes  Lean body mass Yes  Muscle strength Yes  Cardiac capacity Yes  Red blood cell volume Yes  Exercise performance Yes Atherogenic lipid profile* Probably  Total cholesterol  LDL-C  TG  HDL-C  fibrinogen and PAI-1 * Abbreviations: LDL-C, low-density lipoprotein cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; PAl-1, plasminogen activator inhibitor-1 Abbildung mod. nach Cummings, 2003

Features of adult GH deficiency Improved by GH replacement? Features of adult growth hormone (GH) deficiency syndrome and response to therapy (adapted from Reference 65 and other sources) Features of adult GH deficiency Improved by GH replacement?  Atherosclerosis No data  Life expectancy No data  Bone mineral density Yes (after 1 year of treatment)‏ Thin, dry skin; poor venous access Probably Defective sweating Yes Psychosocial problems Yes low self-esteem depression fatigue/listlessness sleep disturbances anxiety emotional lability and impared self control social isolation poor marital and socioeconomic performance Abbildung mod. nach Cummings, 2003